Encapsulation of Turmeric Crude Extracted in Chitosan Hydrogel Beads for Antimicrobial in Animal Health Care Applications

Abstract

Hydrogel is very popular used in medicinal materials due to their properties. The aim of study is to investigate the development of chitosan (CS) hydrogel beads to extend drug-releasing time and enhance the stability of hydrogel beads from decomposition due to surrounding temperature. Gentamicin (GM) is using as a drug model for loading and releasing from hydrogel beads. For this purpose, the effects of ionic gelation of CS and tripolyphosphate (TPP) on various concentrations (1, 3, 5, and 7%w/v) are emphasized. Scanning electron microscopy (SEM) has revealed that CS hydrogel beads are roughly surface with decreasing of the %CS content. The Fourier transform infrared (FT-IR) spectra show a weak band of hydroxyl stretching at 2878 cm-1 of chitosan, the absorption band of the carbonyl stretching of the secondary amide at 1651 cm-1. The releasing solution of CS hydrogel beads exhibit an antimicrobial activity against 4 type of bacterias compared to Chloramphenical. For this reason, indicating that CS hydrogel beads are an appropriate for controlled drug release system to turmeric crude extract.