Encapsulation of silver nanoparticles within micropores of block copolymers constructed by emulsion‐induced method

Ishizu, Koji; Hatoyama, Naomasa; Makino, Masataka; Tokuno, Yoko; Uchida, Satoshi

doi:10.1002/pola.22661

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…As an alternative approach, the utilization of reverse emulsion in the fabrication of well-ordered macroporous films is quite attractive, in which water droplets are dispersed in the organic solvent and are stabilized by surfactants or amphiphilic copolymers, [35][36][37][38][39][40][41][42][43][44] or dispersed temporarily. 45 Recently, films prepared from cellulose, 35 block copolymers, [36][37][38][39][40] comb-like copolymers, 41 and solutions containing Ag + and AuCl 4 À42-44 have been reported.…”

Section: Introductionmentioning

confidence: 99%

Macroporous, protein-containing films cast from water-in-oil emulsions featuring a block-copolymer

et al. 2011

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Patterned biohybrid films show great potential for application in biosensing, bioconversion, and biochips. Their preparation generally involves a multistep procedure including patterned film fabrication and biomolecule immobilization. Here, we report a one-step approach to well-ordered protein-containing films by the self-assembly of a reverse emulsion (water-in-oil), which was stabilized by an amphiphilic block copolymer polystyrene-block-poly(2-hydroxyethyl methacrylate) (PS-b-PHEMA). We investigated the effects of the solvent, polymer concentration, PHEMA chain length, and substrate on the surface morphologies. The merging of the as-formed emulsion droplets, the formation and refilling of the gaps between the pores, and the hierarchical fine structures surrounding the pores were observed. Dynamic evolution results revealed the formation process of the films. Onestep preparation of protein-containing films was achieved by introducing proteins into the reverse emulsion droplets. The protein pattern was further enhanced by the reduced-pressure method, which largely confined the capillary flow. This method is versatile to various water-soluble functional substances and opens a straightforward route for functional honeycomb-patterned porous films.

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Section: Introductionmentioning

confidence: 99%

Macroporous, protein-containing films cast from water-in-oil emulsions featuring a block-copolymer

et al. 2011

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“…[2,16] However, these improvements still need multisteps and hardly avoid the spreading of functional components throughout the film during pattern formation. Some attempts have been reported for the modification of the breath figure method, such as the introduction of water into the organic phase (or the inverse process) through the formation of emulsion; [17][18][19][20][21] but there are still difficulties, such as the disassociated array and size disorder of pores in comparison to the breath figure method. [22,23] Though water miscible tetrahydrofuran has been applied as solvent surfactant, [24][25][26] so far, the area scale of ordered porous films prepared from the emulsion method is not satisfactory despite the use of different levels of water content and humidiAbstract: Here we report the rapid and convenient patterning of proteins on porous polymer film using the inverse microemulsion approach.…”

Section: Introductionmentioning

confidence: 98%

Honeycomb Micropatterning of Proteins on Polymer Films through the Inverse Microemulsion Approach

Liang

Sun

et al. 2011

Chemistry A European J

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Here we report the rapid and convenient patterning of proteins on porous polymer film using the inverse microemulsion approach. Following this method, proteins, which were dissolved in water, were transferred into dichloromethane solution of polymers through the formation of inverse microemulsion by mixing the two solutions. The protein-containing microemulsion droplets accumulated automatically into large and stable ones on the surface of organic solution casting on solid substrates, and formed tightly packed microemulsion droplet arrays driven by surface tension. With the evaporation of organic solvent and water, the microemulsion droplet arrays, which act as the template, turn to honeycomb patterned pores bearing proteins in them. The formed protein patterns can be locally applied for the detection of other proteins through specific recognition. The generality and reproducibility for the formation of BSA/PS microporous film and protein patterning by using different polymers and solvents were demonstrated by investigating surfactant addition, polymer and solvent types, and casting volume on the morphology of the microporous films. A preliminary mechanism for the protein patterning is discussed based on the analysis of the experimental results.

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“…For example, chemotherapeutic drugs, such as paclitaxel, have been extensively studied in the context of polymeric NP encapsulations . Furthermore, significant research has been conducted to study the potential of inorganic materials such as gold, silver, iron oxide, and calcium tungstate (CaWO 4 or CWO for short) NPs in biomedical imaging and treatment applications. − …”

Section: Introductionmentioning

confidence: 99%

Pilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG–PLA Block Copolymer-Encapsulated CaWO₄ Radioluminescent Nanoparticles for Theranostic Applications

Patel

Schorr

Viswanath

et al. 2021

Ind. Eng. Chem. Res.

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Previous studies have shown that calcium tungstate (CaWO 4 ) nanoparticles (NPs) can be used as a radiosensitizing/Xray contrast agent for cancer treatment. However, due to the propensity of calcium tungstate to agglomerate in physiological solutions, there is a need to encapsulate these NPs within poly(ethylene glycol)-poly(D,L-lactic acid) (PEG−PLA) polymeric micelles through a solvent exchange process. Several parameters including solvent type, polymer to NP ratio, mixing method, and lyophilization were studied to optimize the encapsulation and storage procedures for future scale-up. Herein, we report that the cosolvent that was previously used in this procedure (dimethylformamide) can be replaced with a less toxic cosolvent (acetone), the polymer to NP ratio can be reduced from 600:1 to 50:1 without increasing the particle size by 20%, and mixing methods that create a more uniform flow field produce a more homogenous and less polydisperse particle distribution. In addition, our results indicate that sucrose as a lyophilization excipient produces less agglomeration during freeze-drying compared to mannitol. The smaller molecular weight 2 kDa and 2 kDa ("2 k−2 k") PEG−PLA was less prone to agglomeration during freeze-drying compared to 5 k−5 k PEG−PLA.

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Encapsulation of silver nanoparticles within micropores of block copolymers constructed by emulsion‐induced method

Cited by 4 publications

References 22 publications

Macroporous, protein-containing films cast from water-in-oil emulsions featuring a block-copolymer

Macroporous, protein-containing films cast from water-in-oil emulsions featuring a block-copolymer

Honeycomb Micropatterning of Proteins on Polymer Films through the Inverse Microemulsion Approach

Pilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG–PLA Block Copolymer-Encapsulated CaWO₄ Radioluminescent Nanoparticles for Theranostic Applications

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Encapsulation of silver nanoparticles within micropores of block copolymers constructed by emulsion‐induced method

Cited by 4 publications

References 22 publications

Macroporous, protein-containing films cast from water-in-oil emulsions featuring a block-copolymer

Macroporous, protein-containing films cast from water-in-oil emulsions featuring a block-copolymer

Honeycomb Micropatterning of Proteins on Polymer Films through the Inverse Microemulsion Approach

Pilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG–PLA Block Copolymer-Encapsulated CaWO4 Radioluminescent Nanoparticles for Theranostic Applications

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Product

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Pilot-Scale Optimization of the Solvent Exchange Production and Lyophilization Processing of PEG–PLA Block Copolymer-Encapsulated CaWO₄ Radioluminescent Nanoparticles for Theranostic Applications