Encapsulation of Satureja khuzistanica extract in alginate hydrogel accelerate wound healing in adult male rats

Abstract

BackgroundFinding the best dressing for a specific wound had continued from the past to present. The aim of this study was to evaluate the effect of encapsulated extract of Satureja khuzistanica in hydrogel alginate at wound healing.MethodsThirty-two male Wistar rats with a puncture wound in the back of the neck skin were divided randomly into four groups including a control group, Satureja khuzistanica-treated group, hydrogel alginate-treated group, and Satureja khuzistanica encapsulated in hydrogel alginate-treated group. Rats were treated for 22 days. The skin samples were taken on 3rd, 7th, 14th, and 22nd days after treatment for light microscopy. Results were analyzed in accordance with Kruskal-Wallis and Friedman test (for histopathology analysis) by using SPSS v.22 software.ResultsMacroscopically evaluations and measurement of wound size showed increased wound healing process in the treated groups. The complete improvement was created on the 14th day. The wound site was not observed on the 22nd day. But the wound site was observed on the 22nd day in the control group. Also, comparison of the percentage of wound healing between the treated and control groups on 3rd, 7th, 14th, and 22nd days showed a significant difference (p < 0.05). Comparison of the H&E stained sections in the studied groups showed that treated groups were effective on wound healing in comparison with the control group.ConclusionsEncapsulated extract of Satureja khuzistanica in hydrogel alginate may accelerate wound improvement and increase the rate of wound healing without scar formation.

Alginate and its application to tissue engineering

“…The endothelial ancestor cells were properly transplanted on the vehicles that are created from RGDalginate. This supports the cell migration and adhesion and the incorporated gels of alginate releases VEGF to facilities the distribution of the cell [88][89][90].…”

The Protective Effect of Vasopressin on Sperm Parameters and Histopathology of Testicular and Epididymal Tissue in a Rat Model of Testicular Torsion-Detorsion

“…Although standard treatment for testicular TD injury is surgery, some interventions have recently been suggested to reduce injury; including ROS scavenging agents, anti-inflammatory agents, natural products, and synthetic drugs [4]. Antioxidants are able to protect cells and tissues against various diseases particularly disorders caused by ROS [12][13][14][15][16]. Therefore, prescribing antioxidants to reduce oxidative stress seems important and necessary [17][18][19][20][21][22].…”

Determination and Evaluating the Antioxidant Properties of Ziziphus nummularia (Burm.f.) Wight & Arn., Crataegus pontica K.Koch and Scrophularia striata Boiss

“…Concerns about the side effects of chemical drugs, including drug resistance, have led to increased tendencies to use compounds with natural origin, such as natural compounds extracted from medicinal plants [1]. Humanity has historically been highly dependent on medicinal plants for the treatment of variety of diseases and disorders [2][3][4][5][6]. Today, many populations in developing countries need to use medicinal plants to meet their basic medical needs.…”