Encapsulation of Plutonium and Other Radioactive Materials in Welded Containers.

Abstract

In connection with the charging and sealing of plutonium alloy into fuel capsules for LklMPRE (Los Alamos Molten Plutonium Reactor Experiment), production equipment and e procedure have been developed that have general application. Radioactive or other noxious materials are loaded into cylladrical containers without contaminating the outside of the containers, an i nek atmosphere is provided, and the containera are welded shut. The equipment coneista of a welding fixture, atmosphere controls, and a power supply. The procedure depends on careful bsndllng and the convenience of the equipment.

Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential

“…Cell penetrating ability of Tat has also been used in enhancing tumor retention of antibodies. 43 To target aberrant expression of proteins in cancer, Tat-123 I-anti-p21 WAF−1/Cip−1 antibody was delivered into MDA-MB-468 breast cancer cells; the antibody was shown to be transported to the nucleus to block p21-mediated G 1 -S phase arrest, as seen from 35% nuclear radioactivity as compared to 7% for 123 I-anti-p21 WAF−1/Cip−1 without the Tatpeptide. 44,45 In a unique attempt, an anti-DNA antibody 46 itself has been shown to exhibit CPP-like features including transport to the nucleus.…”