Encapsulation of pharmaceutical ingredient linker in metal–organic framework: combined experimental and theoretical insight into the drug delivery

Li, Fumei; Liu, Baohong; Wang, Chunfeng; Zeng, Yongping; Liu, Jianqiang; Gu, Chuying; Lu, Ping; Mei, Lin

doi:10.1039/c6ra06178h

Cited by 52 publications

(25 citation statements)

References 39 publications

(36 reference statements)

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“…Compared to their organic (dendritic macromolecules) or inorganic counterparts (zeolites), MOFs can be functionalized to give ubiquitous ability, as the ligand-producing variety of MOFs can be postmodified, or alternatively, the ligand itself may possess special functional groups [22,23]. In addition to their diverse and versatile framework, MOFs also display extraordinary properties, such as high surface areas, ultrahigh porosity, and thermal stability [24,25], which make them a potential candidate for applications in areas such as gas storage and separation [26,27,28,29,30,31], catalysis [32,33], chemical sensors [34,35], drug delivery, and biomedical imaging [36,37,38,39,40,41]. In this regard, Yaghi et al [42] pioneeringly synthesized a series of MOFs with an exceptionally high surface area (4500 m 2 ·g −1 ) and extra-large pores capable of binding polycyclic organic guest molecules.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

et al. 2018

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Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed.

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Section: Introductionmentioning

confidence: 99%

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

et al. 2018

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“…It is also well known that the coordinating ability of metals irrespective of their similarity in oxidation states could be completely dissimilar. The Zn based MOF has been used for encapsulating pharmaceutical ingredients . Thus it is clear from the above discussion that the microstructure differences noticed by varying the mole ratio between Zn(OAc) 2 and FA is due to the combined effect of coordination between ZnO and FA as well as the secondary interaction between free FA with the FA that is coordinated to ZnO.…”

Section: Resultsmentioning

confidence: 99%

Tunable, Hybrid 1D ZnO Nanostructures Obtained by Using Bio‐renewable Ferulic Acid as Support and its Applications

et al. 2018

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Inorganic oxides such as titanium dioxide (TiO2) and zinc oxide (ZnO) are desired as ultraviolet (UV) filters. Such UV‐filters derived from naturally occurring oxides are promising components for formulating personal care products sustainably. However, UV‐filters based on inorganic oxides pose challenges to formulators and users in terms of strong adherence to skin and high photocatalytic activity. As a means to influence the morphology of such functional oxides, a simple one‐dimensional (1D) ZnO nanorod was synthesized via solvothermal technique assisted by the seed‐growth method. Thus bio‐renewable ferulic acid (FA) was used as a capping and structure‐directing agent to obtain tunable nanostructures such as spheres, sheets, and rods. SEM and TEM analyses revealed the self‐assembled elongated morphology with increased aspect ratio. Based on these as well as other analyses the growth mechanism of zinc oxide functionalized ferulic acid (ZnO@FA) was investigated. ZnO@FA also exhibited broad absorption in the UV−B and A regions, unique antioxidant behavior along with a highly suppressed photocatalytic activity. The ZnO@FA are sustainable, functional materials. These materials are potentially useful in areas such as cosmetics, functional coatings, sensors and solar cells.

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“…Given the channel size and the accessible porosity, the nano‐ 1 is potential candidate in encapsulation of small drug molecules. 5‐Fluorouracil (5‐Fu, 5.3 × 5.0 Å 2 ) is a widely used drug molecule and selected as a drug model in this drug delivery study . The drug‐delivery capacity of the nano‐ 1 was evaluated by impregnating desolvated nano‐ 1 in 5 mL methanol solution containing 5‐Fu (30 mg) with stirring, and investigated the encapsulation of 5‐Fu into them by UV/Vis spectroscopy.…”

Section: Resultsmentioning

confidence: 99%

A Biocompatible Zinc(II)‐based Metal‐organic Framework for pH Responsive Drug Delivery and Anti‐Lung Cancer Activity

Cai

Sheng

Wang

2018

Zeitschrift anorg allge chemie

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By using a mixed ligand approach, a new stable porous metal‐organic framework [Zn3(BTC)2(Me)(H2O)2](MeOH)13 (1) (H3BTC = 1,3,5‐benzenetricarboxylic acid, Me = melamine) was constructed by using the triangular Zn3 secondary building unit, which reveals a 3D scu‐type topology structure with a 1D channel parallel to the c axis. The stability and porosity of 1 was confirmed via the PXRD measurement and gas sorption studies, and its size could be downsized into nanoscale (nano‐1) with the help of PVP (polyvinyl pyrrolidone). Due to its high porosity and non‐toxicity nature, this MOF was used for the 5‐Fu storage/delivery, a moderate high 5‐Fu loading capacity and pH‐dependent drug release behavior could be observed. Furthermore, the in vitro cytotoxicity of the 5‐Fu/nano‐1 composite toward the 293 cells and human lung cancer A549 cells was evaluated by MTT assay.

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Encapsulation of pharmaceutical ingredient linker in metal–organic framework: combined experimental and theoretical insight into the drug delivery

Abstract: This work studied the effect of this relationship on the drug adsorption and delivery of pharmacological molecules. The GCMC has been performed in order to support the drug–matrix interactions in the pore of the material.

Cited by 52 publications

References 39 publications

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

Cyclodextrin-Based Metal-Organic Frameworks (CD-MOFs) in Pharmaceutics and Biomedicine

Tunable, Hybrid 1D ZnO Nanostructures Obtained by Using Bio‐renewable Ferulic Acid as Support and its Applications

A Biocompatible Zinc(II)‐based Metal‐organic Framework for pH Responsive Drug Delivery and Anti‐Lung Cancer Activity

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