Encapsulation of NIR-II AIEgens in Virus-like Particles for Bioimaging

Abstract

The development of organic nanoparticles that fluoresce in the near-infrared, especially in the second near-infrared (NIR-II) window, improves in vivo fluorescence imaging due to deeper penetration and higher spatiotemporal resolution. We report two kinds of NIR-II fluorescent molecules with twisted intramolecular charge-transfer (TICT) and aggregation-induced emission (AIE) characteristics. The virus-like particles (VLPs) of simian virus 40 (SV40) were used as templates to encapsulate the molecules in a well-defined structure (referred to as CH1-SV40 and CH2-SV40). The CH1-SV40 dots exhibited a highly uniform size of 21.5 nm, strong fluorescence, high photostability, and good biocompatibility in vitro and in vivo. Their fluorescence spectrum exhibited a peak at 955 nm, with a tail extending to 1200 nm. Moreover, the CH1-SV40 dots, with a quantum yield of 13.03%, enabled blood vessel imaging and image-guided surgery with a high signal-to-background ratio. Overall, the hybrid nanoparticles represent a new kind of NIR-II AIE nanoprobes for biomedical imaging.

Pt(ii) metallacycles encapsulated by ferritin enable precise cancer combination chemo-photodynamic therapy

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Synthesis and Discovery of Schiff Base Bearing Furopyrimidinone for Selective Recognition of Zn2+ and its Applications in Cell Imaging and Detection of Cu2+

“…The probe FPS with excellent linear relationship for the Zn 2+ detection showed good and weak potential in imaging the exogenous and endogenous Zn 2+ , respectively, which can lead to the exploitation of growingly specific probes, particularly fluorescent for detection of Zn 2+ , Cu 2+ and diagnosis of Zn 2+ , Cu 2+ related diseases. In addition, the DFT calculations results showed how the structure affects the fluorescent behavior of FPS , which may help us to understand the essence of metal ions regulating effect in nature, and even give valuable reference to extend the real application of cell imaging ( Li et al, 2021 ), imaging-guided ( Sun et al, 2019 ), stimuli-responsive bioimaging ( Min et al, 2021 ).…”

Virus-like nanoparticles as a theranostic platform for cancer

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