Encapsulation of Natural Polyphenolic Compounds; a Review

Abstract

Natural polyphenols are valuable compounds possessing scavenging properties towards radical oxygen species, and complexing properties towards proteins. These abilities make polyphenols interesting for the treatment of various diseases like inflammation or cancer, but also for anti-ageing purposes in cosmetic formulations, or for nutraceutical applications. Unfortunately, these properties are also responsible for a lack in long-term stability, making these natural compounds very sensitive to light and heat. Moreover, polyphenols often present a poor biodisponibility mainly due to low water solubility. Lastly, many of these molecules possess a very astringent and bitter taste, which limits their use in food or in oral medications. To circumvent these drawbacks, delivery systems have been developed, and among them, encapsulation would appear to be a promising approach. Many encapsulation methods are described in the literature, among which some have been successfully applied to plant polyphenols. In this review, after a general presentation of the large chemical family of plant polyphenols and of their main chemical and biological properties, encapsulation processes applied to polyphenols are classified into physical, physico-chemical, chemical methods, and other connected stabilization methods. After a brief description of each encapsulation process, their applications to polyphenol encapsulation for pharmaceutical, food or cosmetological purposes are presented.

Microencapsulation of citronella oil by complex coacervation using chitosan-gelatin (b) system: operating design, preparation and characterization

“…The FT-IR spectra obtained after addition of GSE-OPC during crosslinking stage showed similar pattern to GSE-OPC spectra, indicated that GSE-OPC had coated the cooled capsules droplet of Chitosan-Gelatin (B). This result aligned with [37] which explained that if the oligomers of polyphenol are insoluble in the droplets (which refer to capsules); a membrane is formed around them thus encapsulating the droplet. The polyphenolic compound constitutes the droplet, and the crosslinking reaction stabilizes the molecule which was proven by establishment of ester bonds detected from infrared spectroscopy.…”

Effect of Encapsulation on Antimicrobial Activity of Herbal Extracts with Lysozyme

“…Crude extracts from plants with a history of use in folk medicine have been screened in vitro for antibacterial activity (5). Some researchers have reported synergistic eff ect of naturally occurring fl avonoids and other antibacterial agents against resistant strains of bacteria (8,9). Due to the problem of microbial resistance to antibiotics, att ention is given to biologically active components isolated from plant species commonly used in herbal medicine, as they can be used as antimicrobial preparations (10)(11)(12).…”

Characterization and anticancer potential of ferulic acid-loaded chitosan nanoparticles against ME-180 human cervical cancer cell lines

“…Despite having valuable health benefits, bioavailability and clinical efficacy of FA remain substantially limited owing to its lower solubility and permeability in aqueous medium as compared to other solvents such as ethanol, acetone and dimethylsulphoxide (Munin and Lévy 2011;Soobrattee et al 2005). Attempts have been made to increase its solubility and bioavailability through encapsulation in biodegradable polymeric nanoparticles (Vemula et al 2006;Salmaso et al 2007).…”