Encapsulation of magnetic nanoparticles in poly(methyl methacrylate) by miniemulsion and evaluation of hyperthermia in U87MG cells

Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies

“…[20,35].MNPsZnPc-PMMA NPs presented a significant reduction of Ms compared with the bulk values, due to finite-size effects [50].However,this Ms value is enough for encapsulated MNPs to move quickly and be easily separated from the aqueous phase by the action of an external magnetic field gradient, as can be seen in Fig.4B and C.…”

“…These results demonstrate the biocompatibility of the NPs in the absence of both magnetic field and light, preventing toxic effects on the healthy cells [20,23,58].…”

“…These photosensitizers are insoluble in water, leading to self-aggregation in aqueous solutions, which drastically reduces the photosensitizing efficiency when used directly in biological fluids. To avoid these problems, an advanced drug delivery system is needed [9,18].Several kinds of polymeric nanoparticles and polymerization methods have been used to encapsulate magnetic nanoparticles (MNPs) inside polymers [6,[19][20][21]. MNPs present low toxicity and are promising materials for cancer treatment [22,23].…”

“…Another reason was the reaction of the oxidizing initiator (AIBN) with part of the magnetite (Fe 3 O 4 ) converting it to Fe 2 O 3 reducing the concentration of AIBN from the reaction medium[20,21,34]. No residual monomer was detected by GC analysis after lyophilization of the MNPsZnPc-PMMA NPs, allowing application of theseNPs in the biomedical field[36,37].…”

PLA-b-PEG/magnetite hyperthermic agent prepared by Ugi four component condensation

“…XRD results from magnetite, magnetite modified with aldehyde and magnetic composite are shown in Figures 12 curves a)-c) respectively. All the tested materials present peaks at 2" equal to 30.3°, 35.7°, 43.3°, 53.9°, 57.3° and 63.0°, which confirm the spinel structure of the crystal, characteristic of this iron oxide [68], proving that Ugi four component condensation does not change the particles' nature [40,27,69]. Moreover, the crystal size of magnetic particles was calculated by the Scherrer equation [70].…”