Encapsulation of immunoglobulin G by solid-in-oil-in-water: Effect of process parameters on microsphere properties

Marquette, Sarah; Peerboom, Claude; Yates, Andrew; Denis, Laurence; Goole, Jonathan; Amighi, Karim

doi:10.1016/j.ejpb.2013.10.013

Cited by 35 publications

(19 citation statements)

References 29 publications

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“…Indeed, proteins in a solid state are believed to preserve their bioactivity by considerably reducing conformational mobility in comparison to the large structural change found in the dissolved state (Castellanos et al, 2003;Griebenow and Klibanov, 1996). Thus, encapsulation methods involving no protein/water contact have emerged to ensure protein stability within PLGA microparticles such as s/o/w (Marquette et al, 2014), phase separation Thomasin et al, 1998) and other derivative methods (Al-Azzam et al, 2002;Yuan et al, 2009). In this regard, different techniques like spray-drying or spray-freeze drying have been reported in order to prepare small protein particles for subsequent encapsulation into PLGA microparticles.…”

Section: Introductionmentioning

confidence: 99%

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

Swed

Cordonnier

Dénarnaud

et al. 2015

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

Swed

Cordonnier

Dénarnaud

et al. 2015

International Journal of Pharmaceutics

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“…Furthermore, encapsulation of the peptide within a solid matrix could improve stability of the peptide within the lipoidal vehicle. The term solid-inoil-in-water (s/o/w) generally refers to microparticles or nanoparticles that are dispersed in an oily vehicle that is then emulsified in an external aqueous phase [321].…”

Section: Particulates In Pe-based Lipoidal Systemsmentioning

confidence: 99%

Intestinal permeation enhancers for oral peptide delivery

Maher

Mrsny

Brayden

2016

Advanced Drug Delivery Reviews

282

201

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Publication informationAdvanced Drug Delivery Reviews, (Part B): 277-319 Publisher ElsevierItem record/more information http://hdl.handle.net/10197/7800Publisher's statement þÿ T h i s i s t h e a u t h o r s v e r s i o n o f a w o r k t h a t w a s a c c e p t e d f o r p u b l i c a t i o n i n A d v a n c e d D r u g Delivery Reviews. Changes resulting from the publishing process, such as peer review,

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“…The size and size distribution is an important parameter that may affect the drug loading capacity as well as the drug release [24]. The formulations that resulted in successful microsponge preparation (i.e., F4, F5, F7 and F8) were further compared for their size (average diameter) and size distribution (coefficient of variation) as determined through image analysis ( fig.…”

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 99%

“…Moreover, this method is usually applied to ensure high encapsulation efficiency and loading capacity [24]. In another formulation (F7), microsponges were prepared through S/O/W method that is preferably used for encapsulating small sized powdered drugs that can easily dispersed in the organic internal phase.…”

Section: Preparation Of Microspongesmentioning

confidence: 99%

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Zia

Nazir

Khan

et al. 2017

Int J Pharm Pharm Sci

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Objective: Apart from having various physiological functions in the body, ascorbic acid (vitamin C) and cholecalciferol (vitamin D3) also have a key role in skin protection. However, their bioavailability is quite limited in the skin, and therefore, many cosmetic products are supplemented with these vitamins, which are usually associated with stability issues. To avoid these issues, here we report on the preparation of microsponges of these vitamins for topical application. Methods:The microsponges were prepared through various emulsification-solvent evaporation methods involving singleThe organic internal phase was consisted of Eudragit ® RS 100 polymer dissolved in an organic solvent such as acetone or dichloromethane, at a constant polymer to drug ratio of 2:1. The prepared microsponges were characterized for their entrapment efficiency, droplet size and uniformity, core to wall interaction, and surface morphology.Results: It was found that the W/O/W and S/O/W are suitable methods for the preparation of vitamin C microsponges and O/W is a suitable method for the preparation of vitamin D3 microsponges; ensuring an encapsulation efficiency of around 56-59% and 93%, respectively. The average diameter of vitamin C and D3 microsponges was typically around 56-68 μm and 48 μm, respectively. Conclusion:It is possible to encapsulate both water and oil soluble vitamins in a microsponge system at an appreciable entrapment efficiency. The findings of the present study are expected to play a vital role in the development of cosmeceuticals.

show abstract

Encapsulation of immunoglobulin G by solid-in-oil-in-water: Effect of process parameters on microsphere properties

Cited by 35 publications

References 29 publications

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

Intestinal permeation enhancers for oral peptide delivery

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

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