Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Wojtczak, Edyta; Gadzinowski, Mariusz; Makowski, Tomasz; Maresz, Katarzyna; Kubisa, Przemysław; Bednarek, Melania; Pluta, M.

doi:10.1002/pi.5674

Cited by 11 publications

(5 citation statements)

References 67 publications

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“…The degree of crystallinity ( X c ) was evaluated using Eqn :

X_{normalc} (%) = \frac{{Δ H}_{normalm} - {Δ H}_{normalcc}}{{f Δ H}_{m}^{0}} \times 100

where Δ H cc and Δ H m are the cold crystallization and melting enthalpies (J g −1 ), respectively, that were calculated from the cold crystallization and fusion peaks in DSC second heating curves,

{Δ H}_{normalm}^{0}

is the melting enthalpy of the 100% crystalline polymer and f is the weight fraction of each polymer in the blend. The theoretical values of 100% crystalline polymer melting enthalpies (

{Δ H}_{normalm}^{0}

) used to calculate X c were 197 J g −1 for PEG and 93.1 J g −1 for PLLA . The reported enthalpy values have been normalized to the weight fraction of each constituent in the blend.…”

Section: Methodsmentioning

confidence: 99%

“…Among the thermoplastic aliphatic polyesters, poly( l ‐lactic acid) (PLLA) presents excellent biodegradability, biocompatibility and bioresorbability along with transparency and low toxicity . Standard‐grade PLLA is also characterized by high modulus and strength but is brittle and rigid in nature with poor toughness and low melt strength which lead to difficulties in demoulding .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Wojtczak et al . developed polylactide (PLA) block copolymers with PEG for the encapsulation of hydrophobic molecules.…”

Section: Introductionmentioning

confidence: 99%

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The effect of poly(ethylene glycol) mixed with poly(l‐lactic acid) on the crystallization characteristics and properties of their blends

Athanasoulia

Christoforidis

Korres

et al. 2019

Polymer International

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The non‐isothermal and isothermal crystallizations of extruded poly(l‐lactic acid) (PLLA) blends with 10, 20 and 30 wt% poly(ethylene glycol) (PEG) were investigated with differential scanning calorimetry. The formation of α‐form crystals in the blend films was verified using X‐ray diffraction and an increase in crystallinity indexes using Fourier transformation infrared spectroscopy. Crystallization and melting temperatures and crystallinity of PLLA increased with decreasing cooling rate (CR) and showed higher values for the blends. Although PLLA crystallized during both cooling and heating, after incorporation of PEG and with CR = 2 °C min−1 its crystallization was completed during cooling. Increasingly distinct with CR, a small peak appeared on the lower temperature flank of the PLLA melting curve in the blends. A three‐dimensional nucleation process with increasing contribution from nuclei growth at higher CR was verified from Avrami analysis, whereas Kissinger's method showed that the diluent effect of 10 and 20 wt% PEG in PLLA decreased the effective energy barrier. During isothermal crystallization, crystallization half‐time increased with temperature (Tic) for the blends, decreased with PEG content and was lower than that of pure PLLA. In addition, the Avrami rate constants were significantly higher than those of pure PLLA, at the lower Tic. Different crystal morphologies in the PLLA phase were formed, melting in a broader and slightly higher Tm range than pure PLLA. The crystallization activation energy of PLLA decreased by 56% after the addition of 10 wt% PEG, increasing though with PEG content. Finally, PEG/PLLA blends presented improved flexibility and hydrophilicity. © 2019 Society of Chemical Industry

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“…The degree of crystallinity ( X c ) was evaluated using Eqn :

X_{normalc} (%) = \frac{{Δ H}_{normalm} - {Δ H}_{normalcc}}{{f Δ H}_{m}^{0}} \times 100

{Δ H}_{normalm}^{0}

is the melting enthalpy of the 100% crystalline polymer and f is the weight fraction of each polymer in the blend. The theoretical values of 100% crystalline polymer melting enthalpies (

{Δ H}_{normalm}^{0}

) used to calculate X c were 197 J g −1 for PEG and 93.1 J g −1 for PLLA . The reported enthalpy values have been normalized to the weight fraction of each constituent in the blend.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of poly(ethylene glycol) mixed with poly(l‐lactic acid) on the crystallization characteristics and properties of their blends

Athanasoulia

Christoforidis

Korres

et al. 2019

Polymer International

View full text Add to dashboard Cite

show abstract

“…They can be added in functional foods, helping to treat skin diseases and several types of cancer or decrease oxidative stress [ 38 ]. The encapsulation efficiency of polymers was in the range of 27–45% [ 39 ]. Additionally, the prepared capsules with hydrophobic vitamins ensure thermal stability of these sensitive molecules up to 170 °C, which enables further manufacturing of functional products [ 40 ].…”

Section: Encapsulated Agentsmentioning

confidence: 99%

Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

et al. 2023

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There is a growing demand for efficient medical therapies without undesired side effects that limit their application. Targeted therapies such as deliveries of pharmacologically active compounds to a specific site of action in the human body are still a big challenge. Encapsulation is an effective tool for targeted deliveries of drugs and sensitive compounds. It has been exploited as a technique that can manage the required distribution, action and metabolism of encapsulated agents. Food supplements or functional foods containing encapsulated probiotics, vitamins, minerals or extracts are often part of therapies and currently also a consumption trend. For effective encapsulation, optimal manufacturing has to be ensured. Thus, there is a trend to develop new (or modify existing) encapsulation methods. The most-used encapsulation approaches are based on barriers made from (bio)polymers, liposomes, multiple emulsions, etc. In this paper, recent advances in the use of encapsulation in the fields of medicine, food supplements and functional foods are highlighted, with emphasis on its benefits within targeted and supportive treatments. We have focused on a comprehensive overview of encapsulation options in the field of medicine and functional preparations that complement them with their positive effects on human health.

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“…The DDSs based on stereocomplexed assemblies are also attractive for delivery and controlled release applications . Typically, the drug delivery vehicles are prepared by the emulsion‐based method, spontaneous precipitation or nanoprecipitation . In emulsion‐based methods, in particular, the control over particle size and distribution or drug encapsulation efficiency is challenging.…”

Section: Introductionmentioning

confidence: 99%

Microfluidics for producing polylactide nanoparticles and microparticles and their drug delivery application

Brzeziński

Socka

Kost

2019

Polymer International

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This review presents use of the microfluidics technique for the preparation of polylactide (PLA) based particles for developing novel drug delivery systems. Droplet-based microfluidics allow uniform single, double and higher order emulsions to be generated that yield highly uniform microspheres, microcapsules and polymersomes. Typically, the building blocks of these complex microparticle systems are PLA macromolecules, their copolymers with different comonomers and recently stereocomplexes composed of an equimolar mixture of poly(L-lactide) and poly(D-lactide). In addition, the technique offers several advantages over conventional emulsion methods and the highly uniform droplets obtained allow for encapsulation of small drug molecules in polymer network meshes or within their hollow interior. The novel approach in this area is to use the microfluidics technique to produce nanoparticles in the microfluidics channel by micromixing/nanoprecipitation in glass capillary devices. Therefore, this review is divided into three main sections in which we discuss the formation of microspheres from single emulsion droplets, microcapsules and polymersomes from higher order emulsion droplets, and nanoparticles from nanosuspensions in a microfluidic channel. Finally, we compare the drug release from these different particles, focusing mainly on those formed from sensitive or supramolecular networks. Marek Brzeziński graduated with a Master's degree in chemistry from Łódź University of Technology in 2008. He obtained a PhD degree in 2014 at the Centre of Molecular and Macromolecular Studies in Łódź, investigating novel properties of PLA-based materials. He was a Humboldt Fellow at Freie Universität Berlin and Helmholtz-Zentrum Berlin for Materials and Energy, working on a project involving the use of microfluidics to design supramolecular capsules for drug delivery. He is now an assistant professor at the Centre of Molecular and Macromolecular Studies in Łódź and his current research interests include functional polymer design and microparticles and nanoparticles for biomedical applications. Marta Socka graduated with a Master's degree in chemistry from the University of Łódź in 2006. She obtained a PhD degree in 2016 at the Centre of Molecular and Macromolecular Studies in Łódź, studying novel processes of the (co)polymerization of cyclic aliphatic carbonates. Her current research interests include the synthesis and characterization of novel polymeric materials, especially aliphatic polyesters and polycarbonate materials for medical applications. Bartłomiej Kost is doing his PhD at the Centre of Molecular and Macromolecular Studies, Polish Academy of Science, under the supervision of Professor Tadeusz Biela and PhD Marek Brzeziński. He received his MSc degree in Cosmetic Technology at the University of Technology of Łódź in 2017.His current studies mainly focus on the supramolecular chemistry of polymers and nano/microparticle preparation.with size even less than 100 nm which can transport their payloads into the cell's interior.

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Encapsulation of hydrophobic vitamins by polylactide stereocomplexation and their release study

Cited by 11 publications

References 67 publications

The effect of poly(ethylene glycol) mixed with poly(l‐lactic acid) on the crystallization characteristics and properties of their blends

The effect of poly(ethylene glycol) mixed with poly(l‐lactic acid) on the crystallization characteristics and properties of their blends

Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?

Microfluidics for producing polylactide nanoparticles and microparticles and their drug delivery application

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