Encapsulation of Hemin in Metal–Organic Frameworks for Catalyzing the Chemiluminescence Reaction of the H₂O₂–Luminol System and Detecting Glucose in the Neutral Condition

Abstract

Novel metal-organic frameworks (MOFs) based solid catalysts have been synthesized by encapsulating Hemin into the HKUST-1 MOF materials. These have been first applied in the chemiluminescence field with outstanding performance. The functionalized MOFs not only maintain an excellent catalytic activity inheriting from Hemin but also can be cyclically utilized as solid mimic peroxidases in the neutral condition. The synthesized Hemin@HKUST-1 composites have been used to develop practical sensors for H2O2 and glucose with wide response ranges and low detection limits. It was envisioned that catalyst-functionalized MOFs for chemiluminescence sensing would have promising applications in green, selective, and sensitive detection of target analytes in the future.

Glassy carbon electrode modified with hemin and new melamine compounds for H2O2 amperometric detection

“…That is, the proton interchange was, by far, significant in Hm-Den mixture with respect to that revealed by Hm-Dim one. The major structural differences between melamines Dim and Den consisted mainly on their size (Scheme 2) and global shape, planar against vaulted, respectively; at this stage of our knowledge, we hypothesized a partial encapsulation of planar Hm (an already published [31][32][33][34] aptitude of this metaloporphyrine) by a multi-branched structure [31] such as Den, creating a new potential metal-organic framework (MOF) [32][33][34].…”

MIL-53(Fe) MOF-mediated catalytic chemiluminescence for sensitive detection of glucose

“…colorimetric biosensing. However, employment of MOFs as catalyst in CL analysis is rare [24][25][26]. For example, the group of Chen [24] found that Cu-BTC (HKUST-1) could be used as an effective catalyst to significantly enhance the CL emission of a luminol-H 2 O 2 system in basic medium.…”

“…On this basis, a sensitive and selective CL method for CySH was proposed and successfully used for the detection of CySH in human serum samples. By encapsulating Heme into HKUST-1, Chi's group synthesized Hemin@HKUST-1 composite [26]. It was found that the Hemin@HKUST-1 composite displayed excellent catalytic activities toward the luminol-H 2 O 2 CL system both in alkaline and neutral media.…”

Highly sensitive on-site detection of glucose in human urine with naked eye based on enzymatic-like reaction mediated etching of gold nanorods

“…2D). The detection limit was calculated to be 0.1 μM (3σ rule), which is two orders of magnitude lower than other GNRs-based glucose sensors (Liu et al, 2013;Saa et al, 2014) and is almost the lowest among nanoparticle-based glucose sensors (Table S1, Supplementary Information) (Bi et al, 2015;Bo et al, 2013;Jiang et al, 2010;Kong et al, 2014;Luo et al, 2015;Radhakumary and Sreenivasan, 2011;Shen and Xia, 2014;Shiang et al, 2009;Su et al, 2012Su et al, , 2015bXia et al, 2013;Yi et al, 2013;Zayats et al, 2005;Zhao et al, 2015;Zheng et al, 2015). In addition, the small error bar of the data indicates the method has very high stability (Fig.…”