Encapsulation of Diclofenac Molecules into Poly(-Caprolactone) Electrospun Fibers for Delivery Protection

Abstract

Mg-Al Hydrotalcite-like clay (LDH) intercalated with diclofenac anions (HTlc-DIC) was introduced into poly(ε-caprolactone) (PCL) in different concentrations by the electrospinning technique, and mats of nonwoven fibers were obtained and compared to the pristine pure electrospun PCL. The fibers, characterized by X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry, show an exfoliated clay structure up to 3 wt%, a good thermal stability of the diclofenac molecules and a crystallinity of PCL comparable to the pure polymer. The scanning electron microscopy revealed electrospun PCL and PCL composite fibers diameters ranging between 500 nm to 3.0 μm and a generally uniform thickness along the fibers. As the results suggested the in vitro drug release from the composite fibers is remarkably slower than the release from the corresponding control spun solutions of PCL and diclofenac sodium salt. Thus, HTlc-DIC/PCL fibrous membranes can be used as an antinflammatory scaffold for tissue engineering.

Electrostatic self-assembly of polysaccharides into nanofibers

“…An initial burst release of diclofenac from nanofibers would be expected as it has been demonstrated in previous studies [20,[33][34][35], due to the fastest dissolution of Diclofenac at neutral pH [20]. However, Fig.…”

Fabrication, Physico-Chemical, and Pharmaceutical Characterization of Budesonide-Loaded Electrospun Fibers for Drug Targeting to the Colon

“…[1][2][3][4][5][6][7] In recent years, electrospinning has gained widespread interest as a potential polymer processing technique for application in drug delivery. [8][9][10][11][12][13] In this technique, a polymer solution or melt is ejected from a needle tip of a syringe toward a grounded collector plate by applying a high electric field. When electrostatic forces overcome the surface tension of the polymer solution, the electrified fluid forms a jet which extend along a straight line, stretches and, with the solvent evaporation, solidifies into nanofibers.…”

Electrospun poly(L-lactide) membranes containing a single drug or multiple drug system for antimicrobial wound dressings

“…The possibilities for incorporation of DS in micro-and nanofibrous materials based on polycaprolactone by electrospinning have been addressed. [8][9][10] The successful electrospinning of poly(L-lactide) (PLA) solutions containing LHC has been reported. 11,12 The aim of the present study is to develop and characterize nanofibrous membranes from PLA or PLA/poly(ethylene glycol) (PEG), containing DS, LHC, BC or combinations thereof by electrospinning.…”