Encapsulation of BSA in hybrid PEG hydrogels: stability and controlled release

Tourné-Péteilh, Corine; Barège, Maeva; Lions, Mathieu; Martinez, Jean; Devoisselle, Jean-Marie; Aubert-Pouëssel, Anne; Subra, Gilles; Mehdi, Ahmad

doi:10.1039/d1ra03547a

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…According to the literature, the release of several proteins from PEG hydrogels has been extensively investigated. 48,55,56 To validate the proposed model, the diffusion of three proteins namely, Insulin, Trypsin Inhibitor, and Carbonic Anhydrase from PEG 10,000 hydrogel has been simulated. The theoretically predicted values of the diffusion coefficients of the proteins have been shown in Figure 2(a).…”

Section: Resultsmentioning

confidence: 99%

Analysis of diffusion of plant metabolites from polyethylene glycol hydrogels using free volume theory

Natesan

Banerjee

Arockiarajan

et al. 2023

Proc Inst Mech Eng H

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The present work aims to comprehensively analyze the diffusion of plant metabolites from the polyethylene glycol (PEG) hydrogels for controlled release applications. For this study, a mathematical model based on free volume theory has been utilized to simulate the diffusion of low molecular weight plant metabolites. The results demonstrate that the mesh size of the crosslinked network, thereby the diffusion coefficient of the natural compound can be computed using the current framework. The proposed model has also been validated using the experimental data. The diffusion period has been observed to vary within a wide range of 3.42 h for Cinnamaldehyde to 49.25 h for Grandinin. An empirical parametric relationship between the diffusion time and molecular weight of both the hydrogels and natural compounds is established. It appears that the reported modeling approach will be clinically useful for improving the design of the sustained drug delivery systems.

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Section: Resultsmentioning

confidence: 99%

Analysis of diffusion of plant metabolites from polyethylene glycol hydrogels using free volume theory

Natesan

Banerjee

Arockiarajan

et al. 2023

Proc Inst Mech Eng H

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“…This investigation found that modest molecular weight medications could be converted into PEG-based controlled release systems containing big biomacromolecules such as nucleic acids, peptides, and proteins [65][66][67][68][69][70]. The stability and capability of releasing the correct dosage of the active substance of PEG hydrogels are necessary for obtaining a drug's desired therapeutic efficacy [71][72][73]. How soon an active substance is released from PEG-based hydrogels depends on several parameters, including the method used to load the drug, its size, molecular properties, the dosage required for administration, and the release profile [74][75][76].…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

Aldaais¹

2023

Preprint

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Due to their distinct physical, chemical, and biological characteristics, biopolymers, in particular Poly Ethylene Glycol (PEG) and Cellulose, are frequently used in biomedical medicine as drug or vaccine delivery systems. In this study, we have done a systematic review and a meta-analysis to compare current developments in many PEG and cellulose-based hydrogels, including double network hydrogels, injectable hydrogels, sliding hydrogels, conductive hydrogels, responsive hydrogels, and nanocomposite hydrogels. The pharmacokinetic properties, including physicochemical properties, biocompatibility, biodegradability, temperature, and pH, have been studied as these critical factors are to be considered for deciding the suitability of the drug for delivery. Moreover, the study has evaluated the controlled-release parameters such as half-life, circulation time, maximum release percentage of loaded drug released, burst release, maximum release, and drug-release kinetics. Finally, the efficacy and immune response of hydrogel was studied for future choice, including the cellulose hydrogel system in COVID-related long-term vaccine delivery. The finding revealed that cellulose-based hydrogel is effective for vaccine delivery.

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“…To obtain the desired therapeutic efficacy from a designed drug, PEG hydrogels must be stable and capable of releasing the correct dosage of active PSPRJ.000566. 3(4).2022 substance [26][27][28]. The release of an active substance from PEGbased hydrogels depends on multiple factors such as the method of loading of the drug, its size, molecular properties, the dose required for administration, and the release profile [30][31][32].…”

Section: Polyethylene Glycol (Peg)mentioning

confidence: 99%

The Usage of PEG in Drug Delivery Systems- A Mini Review

Yenilmez¹

2022

PSPRJ

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Designing polymeric delivery systems for drugs and genes to implement individual biological functions is an area of continuing interest. Poly (Ethylene Glycol) (PEG) is one of the most successfully adopted materials for designing this kind of drug delivery systems and it exhibits a controllable and sustained release profile. Due to its unique structure, PEG molecules are used to reduce the immunogenicity of drug delivery systems and active substances and to avoid unwanted enzymolysis. PEG based copolymers also play a very important role as biomedical materials due to their biocompatibility, biodegradability and easily controllable characters. This mini review summarizes the state-of-the-art use of PEG in therapeutic applications.

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Encapsulation of BSA in hybrid PEG hydrogels: stability and controlled release

Abstract: Silylated hybrid hydrogels of polyethylene glycol were designed to trap, stabilize and release a model protein (bovine serum albumin). Fine-tuning sol–gel reactions lead to sustained release of BSA over weeks, with good insight of protein stability.

Cited by 5 publications

References 46 publications

Analysis of diffusion of plant metabolites from polyethylene glycol hydrogels using free volume theory

Analysis of diffusion of plant metabolites from polyethylene glycol hydrogels using free volume theory

Meta-Analysis of Polyethylene Glycol and Cellulose-based Polymers in Vaccine and Drug Delivery: A Comprehensive Review

The Usage of PEG in Drug Delivery Systems- A Mini Review

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