Encapsulation of Allopurinol in GO/CuFe2O4/IR MOF-3 Nanocomposite and In Vivo Evaluation of Its Efficiency

Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels

“…Controlling uric acid (UA) production is the best way to prevent and treat hyperuricemia through drug therapy [2] . In the past decades, AP has been used as the most antihyperuricemia drug [14] to control hyperuricemia and gout and to reduce the complications of cardiovascular disease and renal failure [15] . However, using drugs for the treatment of hyperuricemia may give rise to serious side effects such as gastrointestinal intolerance, liver/kidney damage, allergy, and central nervous system disorders [16][17][18] .…”

“…2 In the past decades, AP has been used as the most anti-hyperuricemia drug 14 to control hyperuricemia and gout and reduce the complications of cardiovascular disease and renal failure. 15 However, using drugs for the treatment of hyperuricemia may give rise to serious side effects such as gastrointestinal intolerance, liver/kidney damage, allergy, and central nervous system disorders. [16][17][18] Therefore, it is urgent to find a way to accelerate drug absorption, avoid the first-pass effect and increase drug efficacy, which will improve the bioavailability of anti-hyperuricemia drugs.…”

A Mesoporous Magnetic Fe3O4/BioMOF-13 with a Core/Shell Nanostructure for Targeted Delivery of Doxorubicin to Breast Cancer Cells

“…To provide a more specific context for the current report, it is worth noting that encapsulating drugs within the internal spaces of MOF networks presents a significant opportunity to prevent possible interactions between the drug and other species in blood serum. Such encapsulation also enables the modification of the drug’s lifetime value within the body’s internal environment. , Moreover, drug disorders can be significantly reduced by this method . Biodegradability of the MOFs, ability to uptake a determined dosage of the target drug, biocompatibility with the living cells, and capability for surface functionalization, are other excellences of the MOF scaffolds for the specific utilization in drug delivery .…”