Encapsulation of Acyclovir in new carboxylated cyclodextrin-based nanosponges improves the agent's antiviral efficacy

Chemical and pharmaceutical evaluation of the relationship between triazole linkers and pore size on cyclodextrin–calixarene nanosponges used as carriers for natural drugs

“…24 In principle, their binding abilities and controlled release properties might be tailored and targeted by means of a suitable choice of the linker. 25 This distinctive structure organization promotes molecule complexation and might be responsible for the enhanced solubility, dissolution and stabilization of biomolecules [26][27][28] as well as improves the drug bioavailability by modifying the pharmacokinetic parameters of active constituents. 29 In addition, NSs have the ability to load both hydrophilic and hydrophobic drug molecules because of their inner hydrophobic cavity and external hydrophilic branching, thereby offering unparalleled exibility.…”

β-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs

“…In our study, Acy was selected as hydrophilic antiviral drug model, in virtue of the easy reliability of its biological assay and for its physical properties that cause poor oral bioavailability. For improving the efficacy of Acy treatment and decreasing its adverse side effects, many technological approaches comprising pro-drug preparations, innovative formulations and subcutaneous delivery system that provide a long-lasting sustained release have been proposed [27,28]. The release studies of Acy loaded on our nanoplatform showed a slow release, about 15% after 8 days, without the initial burst effect.…”

Controlled delivery of acyclovir from porous silicon micro- and nanoparticles

“…FTIR spectrum of ACV displayed bands at 1712 cm −1 (C O stretching), 1632 cm −1 (N H bending), 3445 cm −1 (O H stretching), 1106 cm −1 (C O stretching), between 2945-2500 cm −1 (C H stretching), and bands at 3305 and 3184 cm −1 associated with N H stretching (Fig. 6(d)) [37,38]. The spectra of ACV loaded native and TOPSi nanoparticles display new bands at 1634 cm −1 (N H bending), 1700 cm −1 (C O stretching) attributed to the characteristics groups of ACV (( Fig.…”