Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model

Eldin, Noha Essam; Lila, Amr S. Abu; Kawazoe, Kazuyoshi; El-Nahas, Hanan M.; Mahdy, Mahmoud A.; Ishida, Tatsuhiro

doi:10.1016/j.ejps.2015.09.015

Cited by 18 publications

(18 citation statements)

References 37 publications

(18 reference statements)

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“…Authors demonstrated that several parameters affect liposomes retention, such as size and coating surface with polymers, e.g., (PEG), showing that small liposomes or PEGylated ones had higher retention. Interestingly, the pattern of liposome clearance from the pleural cavity was the same comparing normal mice to MPM bearing ones [59].…”

Section: Nanoparticles (Nps) As Novel Promise For Mpmmentioning

confidence: 85%

“…For example, Ando et al demonstrated that an injection into the pleural cavity of pemetrexed loaded into liposomes had more suppressive effect on tumor growth in an orthotopic mesothelioma mouse model, compared to free pemetrexed. Other important studies using liposomes concerns their biodistribution after pleural injection [58,59]. Marazioti et al conducted an animal study by injecting in a pleural cavity different types of liposomes labeled with DiR, comparing their accumulation in normal mice to MPM-bearing mice.…”

Section: Nanoparticles (Nps) As Novel Promise For Mpmmentioning

confidence: 99%

“…MPM researchers have exerted the high expression by MPM cells of CD146 [60] and CD44 [63], two membrane proteins significantly relevant for the diagnosis and prognosis of MPM. Both papers show the high ability of targeted-NPs to be internalized specifically by MPM cells by in vitro experiments; Sakurai et al suggested that targeted NPs tended to accumulate inside tumor bulk more than non-targeted NPs after pleural injection by in vivo experiments [59].…”

Section: Nanoparticles (Nps) As Novel Promise For Mpmmentioning

confidence: 99%

See 2 more Smart Citations

Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Lisini

Lettieri

Nava

et al. 2021

IJMS

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Malignant Pleural Mesothelioma (MPM) is a rare and aggressive neoplasm of the pleural mesothelium, mainly associated with asbestos exposure and still lacking effective therapies. Modern targeted biological strategies that have revolutionized the therapy of other solid tumors have not had success so far in the MPM. Combination immunotherapy might achieve better results over chemotherapy alone, but there is still a need for more effective therapeutic approaches. Based on the peculiar disease features of MPM, several strategies for local therapeutic delivery have been developed over the past years. The common rationale of these approaches is: (i) to reduce the risk of drug inactivation before reaching the target tumor cells; (ii) to increase the concentration of active drugs in the tumor micro-environment and their bioavailability; (iii) to reduce toxic effects on normal, non-transformed cells, because of much lower drug doses than those used for systemic chemotherapy. The complex interactions between drugs and the local immune-inflammatory micro-environment modulate the subsequent clinical response. In this perspective, the main interest is currently addressed to the development of local drug delivery platforms, both cell therapy and engineered nanotools. We here propose a review aimed at deep investigation of the biologic effects of the current local therapies for MPM, including cell therapies, and the mechanisms of interaction with the tumor micro-environment.

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Section: Nanoparticles (Nps) As Novel Promise For Mpmmentioning

confidence: 85%

Section: Nanoparticles (Nps) As Novel Promise For Mpmmentioning

confidence: 99%

Section: Nanoparticles (Nps) As Novel Promise For Mpmmentioning

confidence: 99%

See 1 more Smart Citation

Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Lisini

Lettieri

Nava

et al. 2021

IJMS

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“…Changes in liposome membrane rigidity affect drug release 18 , 19 , as denoted by the more rapid drug release from egg yolk phosphatidylcholine, which possesses a more fluid structure, than from the relatively rigid DPPC 20 . Moreover, lipids constituted in a non-rigid liposomal membrane often cause leakage of entrapped drugs, a condition known to affect the therapeutic index 18 , 19 , 21 . In this case, membrane rigidity is influenced by the characteristics of the lipid composition employed, as well as the addition of cholesterol to the exterior of the liposomal membrane 21 , 22 .…”

Section: Introductionmentioning

confidence: 99%

Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes

Miatmoko

Nurjannah

Nehru

et al. 2021

Sci Rep

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This study aimed to analyze the interaction of primaquine (PQ), chloroquine (CQ), and liposomes to support the design of optimal liposomal delivery for hepatic stage malaria infectious disease. The liposomes were composed of hydrogenated soybean phosphatidylcholine, cholesterol, and distearoyl-sn-glycero-3-phosphoethanolamine-N-(methoxy[polyethyleneglycol]-2000), prepared by thin film method, then evaluated for physicochemical and spectrospic characteristics. The calcein release was further evaluated to determine the effect of drug co-loading on liposomal membrane integrity. The results showed that loading PQ and CQ into liposomes produced changes in the infrared spectra of the diester phosphate and carbonyl ester located in the polar part of the phospholipid, in addition to the alkyl group (CH2) in the nonpolar portion. Moreover, the thermogram revealed the loss of the endothermic peak of liposomes dually loaded with PQ and CQ at 186.6 °C, which is identical to that of the phospholipid. However, no crystallinity changes were detected through powder X-ray diffraction analysis. Moreover, PQ, with either single or dual loading, produced the higher calcein release profiles from the liposomes than that of CQ. The dual loading of PQ and CQ tends to interact with the polar head group of the phosphatidylcholine bilayer membrane resulted in an increase in water permeability of the liposomes.

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“…24,25) However, the therapeutic impact of many liposomal formulations was compromised in various experimental/clinical settings by, at least in part, low drug entrapment efficiency. The commercial impact of liposomes is strengthened by the invention of active "remote" drug loading methods, allowing the encapsulation of several weak base or weak acid drugs with very high drug-to-lipid ratios (encapsulation efficiency up to 90%).…”

Section: Improving Entrapment Efficiencymentioning

confidence: 99%

Liposomal Delivery Systems: Design Optimization and Current Applications

Lila

Ishida

2017

Biological & Pharmaceutical Bulletin

Self Cite

274

136

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The liposome, a closed phospholipid bilayered vesicular system, has received considerable attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of liposomes to encapsulate both hydrophilic and hydrophobic drugs, coupled with their biocompatibility and biodegradability, make liposomes attractive vehicles in the field of drug delivery. In addition, great technical advances such as remote drug loading, triggered release liposomes, ligand-targeted liposomes, liposomes containing combinations of drugs, and so on, have led to the widespread use of liposomes in diverse areas as delivery vehicles for anticancer, bio-active molecules, diagnostics, and therapeutic agents. In this review, we summarize design optimization of liposomal systems and invaluable applications of liposomes as effective delivery systems.

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Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model

Cited by 18 publications

References 37 publications

Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes

Liposomal Delivery Systems: Design Optimization and Current Applications

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Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model

Cited by 18 publications

References 37 publications

Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Local Therapies and Modulation of Tumor Surrounding Stroma in Malignant Pleural Mesothelioma: A Translational Approach

Interactions of primaquine and chloroquine with PEGylated﻿ phosphatidylcholine liposomes

Liposomal Delivery Systems: Design Optimization and Current Applications

Contact Info

Product

Resources

About

Interactions of primaquine and chloroquine with PEGylated phosphatidylcholine liposomes