Encapsulation and Enhanced Release of Resveratrol from Mesoporous Silica Nanoparticles for Melanoma Therapy

Marinheiro, Diogo; Ferreira, B.J.M. Leite; Oskoei, Párástu; Oliveira, Helena; Daniel‐da‐Silva, Ana L.

doi:10.3390/ma14061382

Cited by 40 publications

(43 citation statements)

References 85 publications

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“…Thus, the amount of crystalline resveratrol is mainly explained by steric factors, with higher matrix pore volume and diameter resulting in higher crystalline fraction and with a higher surface area yielding more drug molecules adsorbed as an amorphous surface layer, resulting in a lower crystalline phase fraction. Our results are in accordance with the literature data showing that the resveratrol encapsulation into mesopores of pristine MSN has only led to the amorphization of a part of polyphenol molecules [42].…”

Section: Physico-chemical Characterizationsupporting

confidence: 93%

“…Marinheiro et al reported that A375 melanoma cells are more sensitive to either resveratrol-loaded MSN formulation or free resveratrol than MNT-1 cells. Hence, they obtained IC 50 values of 21.1 µg/mL and 29.5 µg/mL for A375 cell line and MNT-1 cells after 48 h and 72 h of exposure, respectively [42]. Recently, Lin et al found that resveratrol inhibited proliferation, migration, and invasion while promoting apoptosis in human gastric cancer HGC-27 and AGS cells, and alleviated tumor size in vivo, greater effects being observed for resveratrol-loaded MSN than in the case of free polyphenol [45].…”

Section: Cytotoxicity Apoptosis and Cell Cycle Analysismentioning

confidence: 98%

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Resveratrol Encapsulation and Release from Pristine and Functionalized Mesoporous Silica Carriers

et al. 2022

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Resveratrol, a naturally occurring polyphenol, has attracted significant attention due to its antioxidant, cardioprotective and anticancer potential. However, its low aqueous solubility limits resveratrol bioavailability and use. In this work, different mesoporous silica matrices were used to encapsulate the polyphenol and to increase its dissolution rate. Pristine MCM-41, MCM-48, SBA-15, SBA-16, FDU-12 and MCF silica were obtained. The influence of SBA-15 functionalized with aminopropyl, isocyanate, phenyl, mercaptopropyl, and propionic acid moieties on resveratrol loading and release profiles was also assessed. The cytotoxic effects were evaluated for mesoporous carriers and resveratrol-loaded samples against human lung cancer (A549), breast cancer (MDA-MB-231) and human skin fibroblast (HSF) cell lines. The effect on apoptosis and cell cycle were assayed for selected resveratrol-loaded carriers. The polyphenol molecules are encapsulated only inside the mesopores, mostly in amorphous state. All materials containing either pristine or functionalized silica carriers increased polyphenol dissolution rate. The influence of the physico-chemical properties of the mesoporous carriers and resveratrol–loaded supports on the kinetic parameters was identified. Resv@SBA-15-SH and Resv@SBA-15-NCO samples exhibited the highest anticancer effect against A549 cells (IC50 values were 26.06 and 36.5 µg/mL, respectively) and against MDA-MB-231 (IC50 values were 35.56 and 19.30 µg/mL, respectively), which highlights their potential use against cancer.

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Section: Physico-chemical Characterizationsupporting

confidence: 93%

Section: Cytotoxicity Apoptosis and Cell Cycle Analysismentioning

confidence: 98%

Resveratrol Encapsulation and Release from Pristine and Functionalized Mesoporous Silica Carriers

et al. 2022

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“…Resveratrol has also been loaded in uniformly sized (~60 nm) phosphonate and amine modified MSNs in order to improve its in vitro antiproliferative and cytotoxic activity against a prostate cell line. The authors postulated that both phosphonate and amine mesoporous silica nanoparticles showed controlled release compared to the free molecule in 24 h whereas the former were also found to enhance its antiproliferative potential [ 383 ]. Mesoporous silica nanoparticles loaded with curcumin have also been fabricated as a potent anticancer agent [ 384 ].…”

Section: Inorganic-based Delivery Systemsmentioning

confidence: 99%

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Kyriakoudi

Spanidi²,

Mourtzinos

et al. 2021

Plants

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Plants constitute a rich source of diverse classes of valuable phytochemicals (e.g., phenolic acids, flavonoids, carotenoids, alkaloids) with proven biological activity (e.g., antioxidant, anti-inflammatory, antimicrobial, etc.). However, factors such as low stability, poor solubility and bioavailability limit their food, cosmetics and pharmaceutical applications. In this regard, a wide range of delivery systems have been developed to increase the stability of plant-derived bioactive compounds upon processing, storage or under gastrointestinal digestion conditions, to enhance their solubility, to mask undesirable flavors as well as to efficiently deliver them to the target tissues where they can exert their biological activity and promote human health. In the present review, the latest advances regarding the design of innovative delivery systems for pure plant bioactive compounds, extracts or essential oils, in order to overcome the above-mentioned challenges, are presented. Moreover, a broad spectrum of applications along with future trends are critically discussed.

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“…The nanocarriers have attractive textural features such as high surface area with more than 1100 m 2 /g and pore size ranging between 1.5–10 nm with different types of pore orderings. Other structured silicates are SBA-1, SBA-16, and KIT-6 7 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Anti-blastocystosis activity of antioxidant coated ZIF-8 combined with mesoporous silicas MCM-41 and KIT-6

Jermy

Aljindan

Ravinayagam

et al. 2022

Sci Rep

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The biocompatible hybrid Zeolitic imidazolate framework-8 (ZIF-8)/structured silica nanocomposite can be loaded with antioxidants such as curcumin and resveratrol to offer multiple advantages of drug functionalization and structural stability. blastocystosis, an enteric parasite, has various outcomes and its treatment includes drugs which have side effects and do not result in a full cure. We aimed to design novel biocompatible nanocomposites containing natural antioxidant, resveratrol or curcumin and ZIF-8/mesoporous silica. We also assessed their anti-blastocystosis activities as bioactive novel nanocomposites. The nano-silica (MCM-41 and KIT-6) was synthesized using a hydrothermal technique and made composite with ZIF-8 using an ultrasonic technique. The antioxidants, curcumin and resveratrol, were loaded over ZIF-8/MCM-41 and ZIF-8/KIT-6 using a rotary evaporator technique to form novel nanocomposites with bioactive properties. The formulated nanocomposites were characterized. To test their biological activity, suspension of cultured blastocystosis cysts (subtype 3) were exposed to increasing concentrations of nanocomposites and the minimal lethal concentration of each nanocomposite was calculated. The bioactive nanocomposites (ZIF-8/KIT-6, ZIF-8/KIT-6/Resveratrol and ZIF-8/MCM-41/Curcumin) were formulated. Anti-blastocystosis activity of the tested nanocomposites was both dose and time dependent. ZIF-8/KIT-6/Resveratol showed the maximum percentage of growth inhibition (~ 100%) at a concentration of 500 µg/ml after 5 h of exposure. More than 90% of blastocystosis cysts’ growth was significantly inhibited at all concentrations of ZIF-8/MCM-41/Curcumin, with different times of exposure, while it occurred only at the highest concentration of ZIF-8/KIT-6 (800 µg/ml). Using cheap, simple, reproducible and scalable techniques, we nano-formulated innovative bioactive nanocomposites, by incorporating the bioactive ZIF-8 (Zn2+ with imidazole), structured mesosilica and natural antioxidant compounds, curcumin or resveratrol, to generate multifunctional modalities. These eco-friendly, naturally based, safe, economical, biocompatible, and bioavailable nanocomposites are potential nanotherapeutics. The anti-blastocystosis results of these three nanocomposites indicate their potentially promising innovative and safe use as alternative Blastocystosis therapies.

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Encapsulation and Enhanced Release of Resveratrol from Mesoporous Silica Nanoparticles for Melanoma Therapy

Cited by 40 publications

References 85 publications

Resveratrol Encapsulation and Release from Pristine and Functionalized Mesoporous Silica Carriers

Resveratrol Encapsulation and Release from Pristine and Functionalized Mesoporous Silica Carriers

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Anti-blastocystosis activity of antioxidant coated ZIF-8 combined with mesoporous silicas MCM-41 and KIT-6

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