Encapsulation and controlled release of an antimalarial drug using surface functionalized mesoporous silica nanocarriers

Hirayama, Haruka; Amolegbe, Saliu Alao; Islam, Md. Saidul; Rahman, Mohammad Atiqur; Goto, Nonoka; Sekine, Yoshihiro; Hayami, Shinya

doi:10.1039/d1tb00954k

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…19 mg g −1 using TGA, comparable to previously reported MSN loading capacities of 5-70 mg g −1 . 35,36 In this study, we deliberately used uorophores that were contained in the pores but were not covalently bound to the silica matrix, both in order to show the generality of the encapsulation method and to be able to demonstrate adequate pore blocking functionality. Since uorophore molecules were not chemically bond to the MSN matrix, sonication or dissolution in water would remove unbound uorophore by diffusion unless this is prevented by a stable and leakage proof coating.…”

Section: Synthesis Of Dye-doped Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Titania-mediated stabilization of fluorescent dye encapsulation in mesoporous silica nanoparticles

Spitzmüller,

Berson,

Nitschke

et al. 2024

Nanoscale Adv.

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Section: Synthesis Of Dye-doped Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

Titania-mediated stabilization of fluorescent dye encapsulation in mesoporous silica nanoparticles

Spitzmüller,

Berson,

Nitschke

et al. 2024

Nanoscale Adv.

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“…[25] Functionalization improves the NP physical, chemical, and mechanical characteristics, resulting in synergetic effects. [26] For example, Hirayama and coworkers [27] described the encapsulation and release of anti-malaria quinine drug from the surface of functionalized mesoporous silica nano carriers (MCM-41), and optimized the pH and thermal conditions, resulting in improved drug loading capacity due to the synergy between the nanoparticles and the silane coupling agents.…”

Section: Features Of Functional Nanomaterials For Biomedicinementioning

confidence: 99%

Functional Nanomaterials in Biomedicine: Current Uses and Potential Applications

Díez‐Pascual

Rahdar

2022

ChemMedChem

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Nanomaterials, that is, materials made up of individual units between 1 and 100 nanometers, have lately involved a lot of attention since they offer a lot of potential in many fields, including pharmacy and biomedicine, owed to their exceptional physicochemical properties arising from their high surface area and nanoscale size. Smart engineering of nanostructures through appropriate surface or bulk functionalization endows them with multifunctional capabilities, opening up new possibilities in the biomedical field such as biosensing, drug delivery, imaging, medical implants, cancer treatment and tissue engineering. This article highlights up-to-date research in nanomaterials functionalization for biomedical applications. A summary of the different types of nanomaterials and the surface functionalization strategies is provided. Besides, the use of nanomaterials in diagnostic imaging, drug/gene delivery, regenerative medicine, cancer treatment and medical implants is reviewed. Finally, conclusions and future perspectives are provided.

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“…Therefore, encapsulated malaria drugs can be an alternative to decrease Plasmodium ’s resistance to drugs already widely used in endemic regions, because these systems can offer the possibility of the same drugs being used in lower concentrations and with targeted delivery [ 10 , 11 ]. Diverse systems to encapsulate antimalaria drugs have been studied, such as metallic nanoparticles [ 12 , 13 ], lipid nanoparticles [ 14 ], polymers [ 15 ], hydrogels [ 16 ], and mesoporous silica [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Mesoporous Silica for Targeted Drug Delivery of Chloroquine: Synthesis, Characterization, and In Vitro Evaluation

de Andrade,

Schmidt,

Gomes

et al. 2024

Pharmaceutics

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Malaria is a dangerous tropical disease, with high morbidity in developing countries. The responsible parasite has developed resistance to the existing drugs; therefore, new drug delivery systems are being studied to increase efficacy by targeting hemozoin, a parasite paramagnetic metabolite. Herein, magnetic mesoporous silica (magMCM) was synthesized using iron oxide particles dispersed in the silica structure for magnetically driven behavior. The X-ray diffractogram (XRD) and Mössbauer spectra show patterns corresponding to magnetite and maghemite. Furthermore, Mössbauer spectroscopy revealed superparamagnetic behavior, attributed to single magnetic domains in particles smaller than 10 nm. Even in the presence of iron oxide particles, the hexagonal structure of MCM is clearly identified in XRD (low-angle region) and the channels are visible in TEM images. The drug chloroquine (CQ) was encapsulated by incipient wetness impregnation (magMCM-CQ). The N2 adsorption–desorption isotherms show that CQ molecules were encapsulated in the pores, without completely filling the mesopores. BET surface area values were 630 m2 g−1 (magMCM) and 467 m2 g−1 (magMCM-CQ). Encapsulated CQ exhibited rapid delivery (99% in 3 h) in buffer medium and improved solubility compared to the non-encapsulated drug, attributed to CQ encapsulation in amorphous form. The biocompatibility assessment of magMCM, magMCM-CQ, and CQ against MRC5 non-tumoral lung fibroblasts using the MTT assay after 24 h revealed no toxicity associated with magMCM. On the other hand, the non-encapsulated CQ and magMCM-CQ exhibited comparable dose–response activity, indicating a similar cytotoxic effect.

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Encapsulation and controlled release of an antimalarial drug using surface functionalized mesoporous silica nanocarriers

Abstract: Herein we report the encapsulation and release of antimalarial drug quinine (QN) using three nano carriers including MCM-41 (1), its 3-aminopropyl silane and 3-phenylpropyl silane surface functionalized derivatives: aMCM-41(2) and...

Cited by 8 publications

References 26 publications

Titania-mediated stabilization of fluorescent dye encapsulation in mesoporous silica nanoparticles

Titania-mediated stabilization of fluorescent dye encapsulation in mesoporous silica nanoparticles

Functional Nanomaterials in Biomedicine: Current Uses and Potential Applications

Magnetic Mesoporous Silica for Targeted Drug Delivery of Chloroquine: Synthesis, Characterization, and In Vitro Evaluation

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