Encapsulating metal nanoclusters inside porous organic cage towards enhanced radio-sensitivity and solubility

Metallacages and Covalent Cages for Biological Imaging and Therapeutics

“…Due to the depth of penetration of the irradiation, PDT can treat only superficial or endoscope-accessible lesions, the latter of which also inevitably require invasive procedures. Hence, Peng et al reported a radiation-assisted PDT method for the radiation cancer therapy of A549 tumor-bearing mice . The imine-linked CC3 cage 69 was first synthesized from 1,3,5-triformylbenzene and then reduced and protonated to form covalent cages 70 and 71 , respectively.…”

Recent advances in the applications of porous organic cages

“…Liu et al 134 encapsulated Pt nanoclusters in the protonated RCC3 cage, where an accessible and definite cavity led to the homogenous distribution of Pt nanoclusters. The as-obtained composition Pt- in -(HR)CC3 (protonated RCC3) has enhanced solubility in water and showed positive effects in radiation-enhanced cancer therapy for both short-term and long-term treatment (Fig.…”

Highly efficient Markovnikov hydroaminocarbonylation of alkenes and alkynes catalyzed by a “soluble” heterogeneous Pd catalyst

“…(smaller than 3 nm in size) with high stability by taking full advantage of their confined cage environment and incorporated heteroatoms (N, S, and P) inside the cavity as binding and nucleation sites. 20–25 More importantly, POCs have excellent solubility with a well-maintained prefabricated skeleton in certain organic solvents, and thereby could homogenize the heterogeneous ultrafine MNPs to form soluble and stable MNPs with high dispersibility in solution, which could be hardly realized for those insoluble porous hosts. 21 a,b ,22,24 b,c ,25 As a result, the reactants could rapidly and easily access the encapsulated active MNP sites in the cage as in homogeneous catalysis, thus achieving enhanced catalytic activity and selectivity.…”

“…20–25 More importantly, POCs have excellent solubility with a well-maintained prefabricated skeleton in certain organic solvents, and thereby could homogenize the heterogeneous ultrafine MNPs to form soluble and stable MNPs with high dispersibility in solution, which could be hardly realized for those insoluble porous hosts. 21 a,b ,22,24 b,c ,25 As a result, the reactants could rapidly and easily access the encapsulated active MNP sites in the cage as in homogeneous catalysis, thus achieving enhanced catalytic activity and selectivity. In a recent study, we successfully developed a bench-stable triphenyl phosphine-built-in porous organic cage (PPOC) with a large surface area (256 m 2 g −1 ) and hierarchical micro- and mesopores through dynamic imine chemistry, which greatly broadens the functionalities of POCs.…”