Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation

Suwannateep, Natthakitta; Wanichwecharungruang, Supason; Haag, Stefan; Devahastin, Sakamon; Groth, Norbert; Fluhr, Joachim W.; Lademann, Juergen; Meinke, Martina C.

doi:10.1016/j.ejpb.2012.08.010

Cited by 49 publications

(24 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both CUR-EC and CUR-ECMC nanospheres showed similar radical protection factor values as free CUR in lotion, but application on pig ear skin revealed a better radical scavenging activity by CUR encapsulated in the nanospheres than by CUR in lotion. Nanoencapsulation protected CUR from photodegradation and can retain its antioxidant capacity 115 . Ethanol and glycerol catalyzed CUR encapsulated nanoemulsions using cottonseed oil with mild cationic, anionic and nonionic surfactant have been prepared to augment the antioxidant ability of CUR.…”

Section: Biological Activities Of Various Curcuminoid Formulationsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

703

413

View full text Add to dashboard Cite

In recent years, several drugs have been developed deriving from traditional products and current drug research is actively investigating the possible therapeutic roles of many Ayruvedic and Traditional Indian medicinal therapies. Among those being investigated is Turmeric. Its most important active ingredient is curcuminoids. Curcuminoids are phenolic compounds commonly used as a spice, pigment and additive also utilized as a therapeutic agent used in several foods. Comprehensive research over the last century has revealed several important functions of curcuminoids. Various preclinical cell culture and animals studies suggest that curcuminoids have extensive biological activity as an antioxidant, neuroprotective, antitumor, anti-inflammatory, anti-acidogenic, radioprotective and arthritis. Different clinical trials also suggest a potential therapeutic role for curcuminoids in numerous chronic diseases such as colon cancer, lung cancer, breast cancer, inflammatory bowel diseases. The aim of this review is to summarize the chemistry, analog, metal complex, formulations of curcuminoids and their biological activities.

show abstract

Section: Biological Activities Of Various Curcuminoid Formulationsmentioning

confidence: 99%

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Amalraj¹,

Pius

Gopi

et al. 2017

Journal of Traditional and Complementary Medicine

703

413

View full text Add to dashboard Cite

show abstract

“…Additionally, this formulation was proven to form skin lesion abrogation, which causes epithelial loss and skin damage. Furthermore, an encapsulated curcumin nanoparticle formulation penetrates into the skin and subsequently reduces UVB-irradiationinduced radical formation more than free curcumin (124).…”

Section: Skin Diseasesmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanoformulations

Yallapu

Nagesh

Jaggi

et al. 2015

AAPS J

300

177

View full text Add to dashboard Cite

Abstract. Curcumin (diferuloylmethane) is a bioactive and major phenolic component of turmeric derived from the rhizomes of curcuma longa linn. For centuries, curcumin has exhibited excellent therapeutic benefits in various diseases. Owing to its anti-oxidant and anti-inflammatory properties, curcumin plays a significant beneficial and pleiotropic regulatory role in various pathological conditions including cancer, cardiovascular disease, Alzheimer's disease, inflammatory disorders, neurological disorders, and so on. Despite such phenomenal advances in medicinal applications, the clinical implication of native curcumin is hindered due to low solubility, physico-chemical instability, poor bioavailability, rapid metabolism, and poor pharmacokinetics. However, these issues can be overcome by utilizing an efficient delivery system. Active scientific research was initiated in 2005 to improve curcumin's pharmacokinetics, systemic bioavailability, and biological activity by encapsulating or by loading curcumin into nanoform(s) (nanoformulations). A significant number of nanoformulations exist that can be translated toward medicinal use upon successful completion of pre-clinical and human clinical trials. Considering this perspective, current review provides an overview of an efficient curcumin nanoformulation for a targeted therapeutic option for various human diseases. In this review article, we discuss the clinical evidence, current status, and future opportunities of curcumin nanoformulation(s) in the field of medicine. In addition, this review presents a concise summary of the actions required to develop curcumin nanoformulations as pharmaceutical or nutraceutical candidates.

show abstract

“…In addition, the coencapsulation also improved the photostability of resveratrol (Coradini et al, 2014). Against this background, the local delivery of resveratrol and curcumin in LNC via the human skin became interesting as a non-invasive alternative administration route, especially with respect to the local treatment of skin disorders including photocarcinogenesis, photoaging and sunburn (Nicols and Katiyar, 2010;Suwannateep et al, 2012). Considering the topical application, initial in vitro studies showed the capacity of LNC to improve the photostability and promote the retention of resveratrol under UVA radiation (Detoni et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

Skin penetration behavior of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin

Friedrich

Kann

Coradini

et al. 2015

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Encapsulated curcumin results in prolonged curcumin activity in vitro and radical scavenging activity ex vivo on skin after UVB-irradiation

Cited by 49 publications

References 24 publications

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review

Therapeutic Applications of Curcumin Nanoformulations

Skin penetration behavior of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin

Contact Info

Product

Resources

About