2014
DOI: 10.3390/pharmaceutics6030447
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Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer

Abstract: Despite progress in the treatment of pancreatic cancer, there is still a need for improved therapies. In this manuscript, we report clinical experience with a new therapy for the treatment of pancreatic cancer involving the implantation of encapsulated cells over-expressing a cytochrome P450 enzyme followed by subsequent low-dose ifosfamide administrations as a means to target activated ifosfamide to the tumor. The safety and efficacy of the angiographic instillation of encapsulated allogeneic cells overexpres… Show more

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Cited by 18 publications
(14 citation statements)
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“…When the cells were encapsulated and transplanted into pancreatic tumors, growth arrest and in one case complete tumor eradication occurred over the 3‐week study period with minimal immune reaction to the capsules . The approach was later adapted to allogeneic cells and tested in patients with pancreatic cancer, which resulted in improved 1‐year survival rates . Encapsulated genetically engineered Chinese hamster ovary cells expressing human endostatin have effectively inhibited tumor angiogenesis in mice .…”
Section: Applications Of Encapsulation In Cellular Xenotransplantationmentioning
confidence: 99%
See 1 more Smart Citation
“…When the cells were encapsulated and transplanted into pancreatic tumors, growth arrest and in one case complete tumor eradication occurred over the 3‐week study period with minimal immune reaction to the capsules . The approach was later adapted to allogeneic cells and tested in patients with pancreatic cancer, which resulted in improved 1‐year survival rates . Encapsulated genetically engineered Chinese hamster ovary cells expressing human endostatin have effectively inhibited tumor angiogenesis in mice .…”
Section: Applications Of Encapsulation In Cellular Xenotransplantationmentioning
confidence: 99%
“…85 The approach was later adapted to allogeneic cells and tested in patients with pancreatic cancer, which resulted in improved 1-year survival rates. 160,161 Encapsulated genetically engineered Chinese hamster ovary cells expressing human endostatin have effectively inhibited tumor angiogenesis in mice. 162 Similarly, alginate encapsulated human mesenchymal stem cells modified to express endostatin inhibited angiogenesis and reduced the size of glioblastoma tumors in a mouse model over 22 days.…”
Section: Cancermentioning
confidence: 99%
“…Main clinical trials published and for which we have sufficient data are detailed in Table 3 . Main indication is PDAC at an advanced stage (locally advanced and/or metastatic) with phases 1 and 2 trials and one phase 3 [ 101 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 ]. Three types of strategies have been conducted: in situ gene therapy product injection (by means of EUS), vaccination (intradermal or subcutaneous route) and oncolytic virus administration.…”
Section: Clinical Trialsmentioning
confidence: 99%
“…In addition to pancreatic malignancies, ongoing studies are aimed to establish effective gene therapies for pancreatitis, pancreatic pain, and diabetes mellitus. Based on the several completed ( Table 1 ) and ongoing clinical trials [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ] ( Table 2 ), gene therapy offers a promising avenue as a safe and efficient approach [ 51 ].…”
Section: Introductionmentioning
confidence: 99%