Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation

Ruan, Xiuxiu; Shi, Hanping; Xia, Gengfeng; Xiao, Ying; Dong, Jiaxi; Ming, Feiping; Wang, Shenming

doi:10.1016/j.nut.2007.07.002

Cited by 38 publications

(18 citation statements)

References 36 publications

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“…Moreover, there was a significant negative correlation between fecal endotoxins concentrations and the abundance of Bifidobacteria and B. infantis , as observed by others [33, 34]. In addition, there was a significant positive correlation between the fecal levels of endotoxins and Gram-negative Enterobacteriaceae, suggesting that the decrease in Enterobacteriaceae might account for the endotoxins reduction, consistent with the findings of others [35, 36].…”

Section: Discussionsupporting

confidence: 89%

MicroencapsulatedBifidobacterium longumsubsp.infantisATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

Rodes

Saha

Tomaro-Duchesneau

et al. 2014

BioMed Research International

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The gut microbiota is a bacterial bioreactor whose composition is an asset for human health. However, circulating gut microbiota derived endotoxins cause metabolic endotoxemia, promoting metabolic and liver diseases. This study investigates the potential of orally delivered microencapsulated Bifidobacterium infantis ATCC 15697 to modulate the gut microbiota and reduce endotoxemia in F344 rats. The rats were gavaged daily with saline or microencapsulated B. infantis ATCC 15697. Following 38 days of supplementation, the treated rats showed a significant (P < 0.05) increase in fecal Bifidobacteria (4.34 ± 0.46 versus 2.45 ± 0.25% of total) and B. infantis (0.28 ± 0.21 versus 0.52 ± 0.12 % of total) and a significant (P < 0.05) decrease in fecal Enterobacteriaceae (0.80 ± 0.45 versus 2.83 ± 0.63% of total) compared to the saline control. In addition, supplementation with the probiotic formulation reduced fecal (10.52 ± 0.18 versus 11.29 ± 0.16 EU/mg; P = 0.01) and serum (0.33 ± 0.015 versus 0.30 ± 0.015 EU/mL; P = 0.25) endotoxins. Thus, microencapsulated B. infantis ATCC 15697 modulates the gut microbiota and reduces colonic and serum endotoxins. Future preclinical studies should investigate the potential of the novel probiotic formulation in metabolic and liver diseases.

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Section: Discussionsupporting

confidence: 89%

MicroencapsulatedBifidobacterium longumsubsp.infantisATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

Rodes

Saha

Tomaro-Duchesneau

et al. 2014

BioMed Research International

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“…Bifidobacteria are known to reduce intestinal LPS and to improve mucosal barrier function (34)(35)(36)(37). In our study, Mg2 mice had a lower cecal bifidobacteria content at d 4 than Mg+ mice and this was associated with a lower ileal content of ZO-1 and Occ mRNA, 2 tight junction proteins that control gut barrier function.…”

Section: Discussionmentioning

confidence: 45%

Changes in Intestinal Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice

Pachikian

Neyrinck

Deldicque

et al. 2010

The Journal of Nutrition

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Magnesium (Mg) deficiency is a common nutritional disorder that is linked to an inflammatory state characterized by increased plasma acute phase protein and proinflammatory cytokine concentrations. Recent studies have shown that changes in the composition of gut microbiota composition participate in systemic inflammation. In this study, therefore, we assessed the potential role of gut microbiota in intestinal and systemic inflammation associated with Mg deficiency in mice. For this purpose, mice were fed a control or Mg-deficient diet (500 mg vs. 70 mg Mg/kg) for 4 or 21 d. Compared with the mice fed the control diet, mice fed the Mg-deficient diet for 4 d had a lower gut bifidobacteria content (-1.5 log), a 36-50% lower mRNA content of factors controlling gut barrier function in the ileum (zonula occludens-1, occludin, proglucagon), and a higher mRNA content (by approximately 2-fold) in the liver and/or intestine of tumor necrosis factor-alpha, interleukin-6, CCAAT/enhancer binding protein homologous protein, and activating transcription factor 4, reflecting inflammatory and cellular stress. In contrast, mice fed the Mg-deficient diet for 21 d had a higher cecal bifidobacteria content compared with the control group, a phenomenon accompanied by restoration of the intestinal barrier and the absence of inflammation. In conclusion, we show that Mg deficiency, independently of any other changes in nutrient intake, modulates the concentration of bifidobacteria in the gut, a phenomenon that may time-dependently affect inflammation and metabolic disorders in mice.

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“…Gut mucosal injury as a consequence of both post-hemorrhagic perfusion impairment and pulmonary infection might cause bacterial translocation [17][18][19]. Bacterial translocation is defined as the passage of viable bacteria from the gastrointestinal tract through the mucosal epithelium to other sites, such as the MLNs, and may lead to the development of immune dysfunction [multiple organ dysfunctions (MODs)] after hemorrhagic shock [20]. Intestinal, potentially pathogenic, bacterial overgrowth is considered to be an important factor for the development of bacterial translocation in experimental hemorrhagic shock [21].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Hypothermia on Splanchnic Flows and Lung in a Two-Hit Hemorrhagic Shock Model

Deniz¹,

Ağalar²,

Agalar³

et al. 2010

Journal of Surgical Research

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Encapsulated Bifidobacteria reduced bacterial translocation in rats following hemorrhagic shock and resuscitation

Cited by 38 publications

References 36 publications

MicroencapsulatedBifidobacterium longumsubsp.infantisATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

MicroencapsulatedBifidobacterium longumsubsp.infantisATCC 15697 Favorably Modulates Gut Microbiota and Reduces Circulating Endotoxins in F344 Rats

Changes in Intestinal Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice

The Effect of Hypothermia on Splanchnic Flows and Lung in a Two-Hit Hemorrhagic Shock Model

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