“…MS2 (Leviviridae) capsids have been used to design vessels for delivering therapeutic molecules (Wu et al, 1995;Brown et al, 2002;Wu et al, 2005;Galaway and Stockley, 2013;Yan et al, 2014;Pumpens et al, 2016) and for antigen presentation in vaccines (Mastico et al, 1993;Wu et al, 1995;Peabody, 1997;Tumban et al, 2015;Frietze et al, 2016;Pumpens et al, 2016). Similar studies have also been performed with T = 3 jelly-roll capsids (Ren et al, 2006;Barnhill et al, 2007;Lockney et al, 2011;Yildiz et al, 2012;Zeng et al, 2013;Sokullu et al, 2019;Durán-Meza et al, 2020). Understanding protein-protein interactions is an important step in improvising such systems, as was shown in a recent study on MS2 (Biela et al, 2022), where insertions were made to tweak the dimerization interface, allowing the formation of larger capsid structures.…”