“…The third class is based on detailed retinal models reproducing its circuitry, in order to predict the individual or collective responses measured at the ganglion cells level (Pelayo et al, 2004 ; Wohrer and Kornprobst, 2009 ; Lorach et al, 2012 ; Martinez-Alvarez et al, 2013 ). In PRANAS, we are interested in this third class of models because they allow to explore several aspects of retinal image processing such as (i) understanding how to reproduce accurately the statistics of the spiking activity at the population level (Nasser et al, 2013a ), (ii) reconciling connectomics and simple computational rules for visual motion detection (Kim et al, 2014 ), and (iii) investigating how such canonical microcircuits can implement the different retinal processing modules cited in e.g., Gollisch and Meister ( 2010 ). More precisely, the PRANAS platform has integrated and extended the VIRTUAL RETINA simulator (Wohrer and Kornprobst, 2009 ) 1 initially developed in our team to do large scale retina simulations.…”