“…Prostanoids are biosynthesized in the body from arachidonic acid by the action of COX enzymes − and play various physiological roles including smooth muscle constriction or dilation, regulating inflammation, and platelet aggregation or disaggregation . Since the 1960s, many efforts on the chemical synthesis of prostaglandins have been reported, including the elegant strategies designed by Corey, Woodward, Stork, Fuchs, Noyori, Aggarwal, Hayashi, Nicolaou, and others. Because of the high demand of prostaglandins as drugs, there is still a necessity for the development of more efficient routes toward this class of compounds, based on new reactions and strategies.…”