Enantiospecific Analysis of Carboxylic Acids Using Cinchona Alkaloid Dimers as Chiral Solvating Agents
Ming-Yang Mo,
Xiao-Juan Wang,
Ren-Zeng Shen
et al.
Abstract:Cinchona alkaloid derivatives as Brønsted base catalysts have attracted considerable attention in the field of asymmetric catalysis. However, their potential application as chiral solvating agents has not been described. In this research, we investigated the use of the Cinchona alkaloid dimer, namely, (DHQ) 2 PHAL, as a chiral solvating agent for discerning various mandelic acid derivatives through 1 H NMR spectroscopy. The addition of catalytic amounts of DMAP facilitated this process. Our experimental result… Show more
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