Enantioseparation of 4C-Substituted Pyrrolidin-2-One Derivatives on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases

Kažoka, H.; Turovska, Baiba; Upmanis, Toms; Вейнберг, Г.

doi:10.1007/s10337-022-04145-z

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Therefore, the studies upon CSPs and chiral recognition mechanism were always attractive in past decades [10,11,12]. Till now, there have been numerous studies on natural CSPs including polysaccharides [13,14], macrocyclic glycopeptides [15,16], proteins [17], cyclodextrins [18], and arti cial CSPs such as crown ethers [19,20], chiral porous materials [21,22] and Pirkle-type materials [23]. Hence, the development of more versatile CSPs with high enantioselectivity and low cost continues to be a research focus.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Enantiomeric Separation of l-Pro-l-Phe-l-Val-l-Leu Peptide Stationary Phases

et al. 2023

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This study presents the development of three new chiral stationary phases (CSP). Three new peptides CSPs with a main chain of L-proline (L-Pro), L-phenylalanine (L-Phe), L-valine (L-Val) and L-leucine (L-Leu) and different terminals of L-citrulline (L-Cit), L-lysine (L-Lys) and L-tryptophan (L-Typ) immobilized on 3aminopropyltrimethoxysilane modi ed silica gel (APS) were prepared, furthermore, successful analyses and characterizations were conducted using Fourier transform infrared spectra, elemental analysis, and thermogravimetric analysis. After this, the enantioselective performance of the three L-Pro-L-Phe-L-Val-L-Leu peptide stationary phases columns were evaluated. The evaluation used 9 racemic compounds under normal-phase high performance liquid chromatography mode. Optimized enantiomeric separation conditions were established. Under these conditions, the resolutions of urbiprofen, naproxen, benzoin, 1,1'bi-2-naphthol and ketoprofen on the CSP-1 column were 1.61, 2.0, 0.62, 0.52, and 1.20, respectively. In addition, the reproducibility of the CSP-1 column was also investigated. The results of the investigation illustrated that the stationary phases have good reproducibility (RSD = 0.12%, n = 5).

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Section: Introductionmentioning

confidence: 99%

Preparation and Enantiomeric Separation of l-Pro-l-Phe-l-Val-l-Leu Peptide Stationary Phases

et al. 2023

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Evolution of Stability-Indicating Method in the Quantification of Related Substances and Degradation Products of Elagolix Sodium: Quality by Design-Driven Approach Utilizing Ultra-high Performance Liquid Chromatography

et al. 2022

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Preparation and Enantiomeric Separation of L-Pro-L-Phe-L-Val-L-Leu Peptide Stationary Phases

Guo

Shang

Wei

et al. 2023

Preprint

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This study presents the development of three new chiral stationary phases (CSP). Three new peptides CSPs with a main chain of L-proline (L-Pro), L-phenylalanine (L-Phe), L-valine (L-Val) and L-leucine (L-Leu) and different terminals of L-citrulline (L-Cit), L-lysine (L-Lys) and L-tryptophan (L-Typ) immobilized on 3-aminopropyltrimethoxysilane modified silica gel (APS) were prepared, furthermore, successful analyses and characterizations were conducted using Fourier transform infrared spectra, elemental analysis, and thermogravimetric analysis. After this, the enantioselective performance of the three L-Pro-L-Phe-L-Val-L-Leu peptide stationary phases columns were evaluated. The evaluation used 9 racemic compounds under normal-phase high performance liquid chromatography mode. Optimized enantiomeric separation conditions were established. Under these conditions, the resolutions of flurbiprofen, naproxen, benzoin, 1,1'-bi-2-naphthol and ketoprofen on the CSP-1 column were 1.61, 2.0, 0.62, 0.52, and 1.20, respectively. In addition, the reproducibility of the CSP-1 column was also investigated. The results of the investigation illustrated that the stationary phases have good reproducibility (RSD = 0.12%, n = 5).

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Enantioseparation of 4C-Substituted Pyrrolidin-2-One Derivatives on Polysaccharide and Macrocyclic Glycopeptide Chiral Stationary Phases

Cited by 3 publications

References 14 publications

Preparation and Enantiomeric Separation of l-Pro-l-Phe-l-Val-l-Leu Peptide Stationary Phases

Preparation and Enantiomeric Separation of l-Pro-l-Phe-l-Val-l-Leu Peptide Stationary Phases

Evolution of Stability-Indicating Method in the Quantification of Related Substances and Degradation Products of Elagolix Sodium: Quality by Design-Driven Approach Utilizing Ultra-high Performance Liquid Chromatography

Preparation and Enantiomeric Separation of L-Pro-L-Phe-L-Val-L-Leu Peptide Stationary Phases

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