Enantioseparation by zeolitic imidazolate framework-8-silica hybrid monolithic column with sulfobutylether-β-cyclodextrin as a chiral additive in capillary electrochromatography

Gao, Lidi; Cui, Hongshou; Guo, Xinyu; Dong, Qing; You, Xingyu; Guo, Xinshu; Qin, Shili; Jia, Lei

doi:10.1007/s00604-023-05908-7

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Co-solvents could provide a way to address the issue of insoluble drugs, but they also lead to change in permeability [12]. SBE-β-CD [13][14][15][16][17][18], a new pharmaceutical excipient often used as a co-solvent, has been included in USP44-NF39 under the name Betadex Sulfobutyl Ether Sodium, and is currently available as Captisol ® [19,20] and Dexolve ® [21]. It is widely used in biologics and insoluble drugs [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

Yang,

Zhang,

Huang

et al. 2023

Pharmaceutics

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Permeability has an important effect on drug absorption. In this study, the effect of different concentrations of sodium sulfobutyl ether-β-cyclodextrin (SBE-β-CD) on the absorption of ranitidine was investigated to examine the mechanism of permeability changes. The results of a parallel artificial membrane permeability assay (PAMPA) showed that increasing the concentration of sodium sulfobutyl ether-β-cyclodextrin, 0, 0.12% (w/v), 0.36% (w/v) and 3.6% (w/v), respectively, caused the apparent permeability coefficient of ranitidine to decrease to 4.62 × 10−5, 4.5 × 10−5, 3.61 × 10−5 and 1.08 × 10−5 in Caco-2 cells, respectively. The same results were obtained from an oral pharmacokinetic study in rats. Further studies indicated that SBE-β-CD significantly increased the zeta potential of ranitidine. SBE-β-CD interacted with ranitidine charges to form a complex that reduced ranitidine permeability, and SBE-β-CD should be chosen with caution for drugs with poor permeability.

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Section: Introductionmentioning

confidence: 99%

Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

Yang,

Zhang,

Huang

et al. 2023

Pharmaceutics

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De novo synthesis of α-Alk-β-CD: An organic–inorganic hybrid chiral stationary phase for enhanced enantioseparation efficiency and its recognition mechanism research

Zhang,

Bai,

Han

et al. 2024

Journal of Molecular Liquids

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Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

Rui,

Jing,

Jia-Qi

et al. 2023

Preprint

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Permeability has an important effect on drug absorption. In this study, the effect of different concentrations of sodium sulfobutyl ether-β-cyclodextrin (SBE-β-CD) on the absorption of ranitidine was investigated to examine the mechanism of permeability changes. The results of parallel artificial membrane permeability assay (PAMPA) showed that increasing the concentration of sodium sulfobutyl ether-β-cyclodextrin, 0, 0.12% (w/v), 0.36% (w/v) and 3.6% (w/v), respectively, the apparent permeability coefficient of ranitidine decreased to 4.62×10-5 , 4.5×10-5 , 3.61×10-5 and 1.08×10-5 in Caco-2 cells, respectively. The same results were obtained from oral pharmacokinetic study in rats; Further studies indicated that SBE-β-CD significantly increased the zeta potential of ranitidine. SBE-β-CD interacted with ranitidine charges to form a complex that reduced ranitidine permeability, and SBE-β-CD should be chosen with caution for drugs with poor permeability.

show abstract

Enantioseparation by zeolitic imidazolate framework-8-silica hybrid monolithic column with sulfobutylether-β-cyclodextrin as a chiral additive in capillary electrochromatography

Cited by 3 publications

References 35 publications

Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

De novo synthesis of α-Alk-β-CD: An organic–inorganic hybrid chiral stationary phase for enhanced enantioseparation efficiency and its recognition mechanism research

Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

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