Enantioselektive Hydrierung von Isochinolinen

Owing to the dehydrogenative rearomatization of hydrogenation product and poisoning effect of nitrogen atom, asymmetric hydrogenation of polycyclic nitrogen‐containing heteroaromatics is still a great challenge. Herein, through in situ protection of hydrogenation products with acetic anhydride to inhibit rearomatization and poisoning effect, a novel iridium‐catalyzed enantioselective hydrogenation of polycyclic nitrogen‐containing heteroaromatics – pyrrolo/indolo[1,2‐a]quinoxalines and phenanthridines – has been successfully developed, providing a facile access to chiral dihydropyrrolo/indolo[1,2‐a]quinoxalines and dihydrophenanthridines with up to 98% ee. The strategy features broad substrate scope, easy operation and potential medicinal application.magnified image

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Asymmetrische Hydrierung disubstituierter Furane

Wysocki

Ortega

Glorius

2014

Angewandte Chemie

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Enantioselektive Hydrierung von Isochinolinen

Cited by 20 publications

References 17 publications

Enantioselective Hydrogenation of Pyrrolo[1,2‐a]pyrazines, Heteroaromatics Containing Two Nitrogen Atoms

Enantioselective Hydrogenation of Pyrrolo[1,2‐a]pyrazines, Heteroaromatics Containing Two Nitrogen Atoms

Iridium‐catalyzed Asymmetric Hydrogenation of Polycyclic Pyrrolo/Indolo[1,2‐a]quinoxalines and Phenanthridines

Asymmetrische Hydrierung disubstituierter Furane

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