Enantioselective Total Synthesis of Sacubitril

Kaur, Amanpreet; Gehlawat, Anju; Prakash, Ranjana; Pandey, Satyendra Kumar

doi:10.1002/slct.202102506

ChemistrySelect

2021

DOI: 10.1002/slct.202102506

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Enantioselective Total Synthesis of Sacubitril

Amanpreet Kaur

Anju Gehlawat

Ranjana Prakash

et al.

Abstract: An efficient enantioselective approach of Sacubitril 1 (a NEP inhibitor) which is used as a combination drug with Valsartan to treat heart failure, is described. The synthesis features the Evan's asymmetric alkylation, Sharpless asymmetric diydroxylation (AD) and Heck coupling reactions as key steps.

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Enantioselective Total Synthesis of Sacubitril

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References 29 publications

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