Enantioselective Synthesis of Protected Cyanohydrins

Biocatalytic enantioselective preparation of phenothiazine-based cyanohydrin acetates: kinetic and dynamic kinetic resolution

“…This is in accordance with the more general proposal that oxynitrilases dislike polycyclic aldehydes. 5 The enantioselective acylation of racemic cyanohydrins [5][6][7][8][9][10] and the enantioselective alcoholysis of racemic cyanohydrin esters 6,7,9,[11][12][13][14] in organic solvents have been widely used in the presence of a suitable lipase. The main disadvantages of the traditional resolution method are, however, the maximum 50% theoretical yield of one enantiomer and the dependence of enantiomeric excess (ee) on the conversion of a reaction.…”

Enantioselective preparation of (R) and (S)-3-hydroxycyclopentanone by kinetic resolution

“…Cyclopentane-1,3-diol, benzyl bromide, silver oxide, sodium dichromate, sulfuric acid, diethyl ether, acetone, ethanol, MTBE, [39]. 1 H and 13 C NMR spectra were recorded on a Bruker Advance 400 (400 MHz and 100 MHz, respectively) instrument and were internally referenced to residual solvent signals.…”

Supported Ionic Liquid‐Like Phases (SILLPs) as Immobilised Catalysts for the Multistep and Multicatalytic Continuous Flow Synthesis of Chiral Cyanohydrins

“…The last step to complete the process is the continuous kinetic resolution of the cyanohydrin ester obtained after the second step. This process is a well stablished reaction under batch conditions . A bioreactor was prepared as a fix bed reactor with Novozyme 435 ( R‐III ) to evaluate the feasibility of this approach.…”