Enantioselective synthesis of isoxazole-containing spirooxindole tetrahydroquinolines via squaramide-catalysed cascade reactions

Abstract

A class of o‐sulfonylaminostyryl isoxazole synthons were designed and demonstrated to be useful building blocks in asymmetric cascade aza‐Michael/Michael reaction with 3‐olefinic oxindoles. This squaramide‐catalysed cascade reaction afforded structurally complex...