Enantioselective Synthesis of cis and trans 4‐Aminopipecolic Acids as γ‐Amino Acids for the Construction of Cyclic RGD‐Containing Peptidomimetics Antagonists of α_Vβ₃ Integrin

Abstract

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Fishing in the Toolbox of Cyclic Turn Mimics: a Literature Overview of the Last Decade

“…[15,16] Thus, a number of modifications have been realized on this scaffold to both stabilise specific folding modes and enhance the biological activity of the natural sequences. [17][18][19] As example, conformational analysis of linear and cyclic peptides incorporating cyclopropane pipecolic acids 2 were reported (Scheme 1). [20] The general synthesis of 2 involved as the key step a Pdcatalyzed methoxycarbonylation of the optically pure enol phosphate 4 prepared from commercially available protected lactam 3.…”