A new lignan, arborlignan A, along with five known substances, neoechinulin A, 4-hydroxy-3,5-dimethoxybenzaldehyde, 3,3′-dimethoxy-4,4′-dihydroxystilbene, β-hydroxypropiovanillone, and coniferyl aldehyde, are isolated from Schefflera arboricola. Their structures are elucidated by mass spectrometry and nuclear magnetic resonance spectroscopy experiments and by comparison with literature data. These compounds are isolated from the genus Schefflera for the first time.