Enantioselective rhodium-catalyzed hydroacylation to access the four stereoisomers of anti-rodent difenacoum

Jacolot, Maïwenn; Moebs‐Sanchez, Sylvie; Popowycz, Florence

doi:10.1016/j.tetlet.2017.03.034

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…In 1975, DIF was developed amidst increasing concern about warfarin-resistant rats [ 3 ]. The anticoagulant activity of DIF is more effective and toxic than the first-generation anticoagulant rodenticides, such as warfarin, because of the introduction of substituted tetralinyl on the side chain [ 4 , 5 ]. DIF can act as an anti-vitamin K anticoagulant to block the vitamin K cycle, which stops the activity of the vitamin K-dependent clotting factor and impairs the biosynthesis of a variety of coagulation functions [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

An Innovative Nanobody-Based High-Biocompatibility Gold Interdigitated Microelectrode Electrochemical Bioimpedance Sensor for the Ultrasensitive Detection of Difenacoum in Human Serum

Guo

Wang

et al. 2021

Materials

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Difenacoum (DIF) is one of the most widely used anticoagulant rodenticides. However, accidental or intentional ingestion of DIF seriously threatens humans and other non-target species. Therefore, a rapid and sensitive detection method to quantify DIF is urgently needed. In this study, one anti-DIF nanobody (Nb) was assembled on the surface of a gold interdigitated microelectrode (IDME) using an Au–S bond to fabricate a bioimpedance sensor. To improve the immobilization amount of Nbs on the electrode, a polycrystalline gold IDME was prepared to provide a larger surface and better biocompatibility. Thus, a novel and ultrasensitive bioimpedance sensor based on electrochemical impedance spectroscopy (EIS) was designed for the determination of DIF, and it displayed good reproducibility and stability in human serum. The proposed bioimpedance sensor displayed a wide working range, between 0.1–1000 pg/mL, with a limit of detection (LOD) of 0.1 pg/mL of DIF. This method exhibited excellent performance, good sensitivity, and reproducibility and achieved the highest sensitivity of all currently existing methods used to quantify DIF. The highly sensitive DIF detection of this proposed bioimpedance sensor indicates its potential as an efficacious approach for DIF monitoring in human serum with high accuracy and precision.

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