Enantioselective pinacol coupling reaction of aromatic aldehydes catalyzed by chiral vanadium complexes

The Electron-Way: Metal-Catalyzed Reductive Umpolung Reactions of Saturated and α,β-Unsaturated Carbonyl Derivatives

“…61 In addition, chiral molybdenum and vanadium catalysts 68 and 69, derived from a C-N-reduced salen ligand, showed good enantioselectivities (entries 10 and 11). 62,63 The regular Schiff base salen complexes with a carbon-nitrogen double bond instead led only to racemic products and low diastereoselectivity.…”

Vanadium, niobium and tantalum

“…73 Chiral vanadium-salen complexes were utilised both in the asymmetric synthesis of cyanohydrin trimethylsilyl ethers from aldehydes and trimethylsilyl cyanide 74 as well as in the enantioselective pinacol coupling reaction of aromatic aldehydes. 75 All three group V metals were shown to act as good oxidation catalysts. For instance, chiral vanadium Schiff-base complexes were able to oxidise sulfides to sulfoxides with excellent enatioselectivity.…”

Probing the mechanism of benzaldehyde reduction to chiral hydrobenzoin on the CNT surface under near-UV light irradiation

“…[15][16][17][18][19] Over the past few decades, most research on this topic has focused on exploring chiral Ti(IV)-salen complex, Mo and V catalysts. [20][21][22][23] In fact, the pinacol coupling reaction can also be achieved under sunlight irradiation with the addition of hydrogen-donating reagents such as alcohols (e.g. MeOH, EtOH, i-PrOH) without using toxic metal complex catalysts (Scheme 1).…”