“…A number of different enantioselective methodologies for the α-chlorination of aldehydes have been reported in literature, and the enantiomeric excess of the product depends on the catalyst, the chlorination agent and the reaction conditions [16,17,18,19,20]. For the chlorination of long chain aldehydes, we selected a modified procedure employing (2 R ,5 S )-2-( tert -butyl)-3,5-dimethylimidazolidin-4-one trifluoroacetate as the organo-catalyst and 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dien-1-one as the chlorination agent [21].…”