Abstract:A newly tertiary amine-thiourea organocatalyst has successfully developed and applied into the asymmetric Michael addition of pyrazolin-5-one to nitroalkenes. The catalyst system performed well with a low catalyst loading of 5 mol% under mild reaction conditions. A series of synthetically and pharmaceutically useful chiral pyrazolone derivatives were obtained in high yields (up to 95%) with good enantioselectivities (up to 88 % ee).
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