Enantioselective Gas Chromatographic Analysis of Cyclopropane Derivatives

Abstract

Chirasil-b-Dex was used as chiral stationary phase for the enantioselective gas chromatographic analysis of several new chiral cyclopropane derivatives. The GC method provides information about the chemical yields of the cyclopropane products, enantioselectivity, substrate specifity, and catalytic activity of the chiral catalysts used in the inter-and intra-molecular cyclopropanation reactions and avoids time-consuming work-up procedures.

Organic/Hybrid Nanoparticles and Single‐Walled Carbon Nanotubes: Preparation Methods and Chiral Applications

“…Consequently, continuous efforts have been made to promote the availability of drugs with single pure enantiomers. Most of these efforts were chemical or chemoenzymatic‐based methods, the success of which heavily relies on the accurate determination of the enantiomeric purity of pure/enriched enantiomers . The latter can be achieved via nuclear magnetic resonance (NMR) spectroscopy, polarimetry, or gas or liquid chromatography methods.…”

“…Interestingly, it has been noted that size‐dependent properties, like optical properties, are present for organic NPs even at 100 nm, unlike the inorganic NPs. They are effective for chiral separation through their specific enantioselective adsorption, especially when they are used as stationary or pseudo‐stationary phases in chiral chromatographic separation of particular interest …”

“…The properties of NCs are intermediate of that of molecules and that of bulk matter . In bulk matter, the properties do not depend on the number of molecules on its surface, unlike in NCs, where the properties depend on NC size . A significant percentage of the molecules can be expected to be on the surface.…”

“…In other words, quantum mechanics will be in play while discussing the properties of NCs. This is due to the fact that all their properties will be a direct consequence of the quantized degrees of freedom the crystals possess …”

Enantioseparation and determination of 2,2‐dimethylcyclopropanecarboxamide and corresponding acid in the bioconversion broth by gas chromatography

“…They possess a wide variety of biological properties, including enzyme inhibition, antifungal, herbicidal, antimicrobial, antibiotic, antibacterial, antitumor and antiviral activities (Ghanem et al, 2005). In the past two decades, great efforts have been made to explore the stereocontrolled synthesis of substituted cyclopropanes.…”