Enantioselective extraction of phenylsuccinic acid in aqueous two-phase systems based on acetone and β -cyclodextrin derivative: Modeling and optimization through response surface methodology

Wang, Jun; Liu, Qi; Rong, Liya; Ye, Hua; Jiao, Feipeng; Chen, Xiaoqing

doi:10.1016/j.chroma.2016.06.054

Cited by 8 publications

(1 citation statement)

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“…The first is based on the addition of a chiral selector, i.e., β-cyclodextrin derivatives, copper-β-cyclodextrin complexes, tartaric acid derivatives, proteins or microbial cells to ABS formed from a polymer–polymer combination, micellar systems of polar solvents and salts [ 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. The second method utilizes the addition of one substance that acts simultaneously as a phase former and a chiral selector [ 114 , 115 , 116 ]. Recently, chiral ionic liquids (CILs) have found application as chiral phase formators as well as chiral selectors in ABS [ 8 ].…”

Section: Cils In Analytical Chemistrymentioning

confidence: 99%

Chiral Ionic Liquids: Structural Diversity, Properties and Applications in Selected Separation Techniques

Flieger

Feder‐Kubis

Tatarczak-Michalewska

2020

IJMS

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Ionic liquids (ILs) are chemical compounds composed of ions with melting points below 100 °C exhibiting a design feature. ILs are commonly used as the so-called green solvents, reagents or highly efficient catalysts in varied chemical processes. The huge application potential of ionic liquids (IL) justifies the growing interest in these compounds. In the last decade, increasing attention has been devoted to the development of new methods in the synthesis of stable chiral ionic liquids (CILs) and their application in various separation techniques. The beginnings of the successful use of CILs to separate enantiomers date back to the 1990 s. Most chiral ILs are based on chiral cations or chiral anions. There is also a limited number of CILs possessing both a chiral cation and a chiral anion. Due to the high molecular diversity of both ions, of which at least one has a chiral center, we have the possibility to design a large variety of optically active structures, thus expanding the range of CIL applications. Research utilizing chiral ionic liquids only recently has become more popular. However, it is the area that still has great potential for future development. This review aimed to describe the diversity of structures, properties and examples of applications of chiral ionic liquids as new chiral solid materials and chiral components of the anisotropic environment, providing chiral recognition of enantiomeric analytes, which is useful in liquid chromatography, countercurrent chromatography and other various CIL-based extraction techniques including aqueous biphasic (ABS) extraction systems, solid–liquid two-phase systems, liquid–liquid extraction systems with hydrophilic CILs, liquid–liquid extraction systems with hydrophobic CILs, solid-phase extraction and induced-precipitation techniques developed in the recent years. The growing demand for pure enantiomers in the pharmaceutical and food industries sparks further development in the field of extraction and separation systems modified with CILs highlighting them as affordable and environmentally friendly both chiral selectors and solvents.

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