Enantioselective Electrochemical Sensors

Abstract

The discrimination between enantiomers is becoming one of the most important fields of modern analytical chemistry, especially for pharmaceutical products, clinical analysis, and food analysis. The introduction of enantioselective electrochemical sensors in enantioanalysis increases the reliability of the measurements. Three types of enantioselective electrochemical sensors are proposed for enantioselective analysis: potentiometric, enantioselective electrodes, amperometric immunosensors, and amperometric biosensors. The principle of enantiomer recognition is the same for all types of proposed electrochemical sensors: to find a lock for the key, where the key is the enantiomer, and the lock is a molecule with a special architecture, an antibody, or an enzyme.

Chiral salen Mn(III) complex-based enantioselective potentiometric sensor for l-mandelic acid

“…Chiral discrimination became an area of considerable research interests because of its importance in almost all fields of biological, chemical and pharmaceutical sciences [1,2]. The stereoselectivity of chemical and biochemical processes depends on recognition and single molecule enantiomer discrimination [3,4].…”

Enantioselective, Potentiometric Membrane Electrodes Based on Cyclodextrins for the Assay ofL‐ andD‐2‐Hydroxyglutaric Acid

“…Different types of chiral selectors have been used in electrochemical enantioanalyses (Stefan et al 2001) such as maltodextrins, macrocyclic antibiotics, and cyclodextrins (CDs). In aqueous solutions, cyclodextrins can form host-guest complexes (Fanali 2000;Armstrong 1997).…”

Synthesis of New Optically Active d-Glucosamine-Pyrrole Derivatives

“…[7][8][9] In addition, analytical applications for these electrodes, including chiral recognition, have been developed. [10][11][12] Despite interest in using chiral pyrroles in these important applications, their use is limited by the synthesis of suitable and inexpensive chiral pyrrole units.…”