Enantioselective effect of chiral prothioconazole on the conformation of bovine serum albumin

Zhu, Meiqing; Pang, Xiaohui; Wang, Kangquan; Sun, Long; Wang, Yi; Hua, Rimao; Chen, Shi; Yang, Xiaofan

doi:10.1016/j.ijbiomac.2023.124541

Cited by 16 publications

(1 citation statement)

References 46 publications

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“…Over the past decades, fluorescence sensors have undergone significant development, proving to be a versatile option in the field of analytical chemistry 14 , 15 . The current interest in these sensors is backed by a multitude of merits, including their sensitivity, selectivity, minimal molecular impact, cost and time effectiveness without being unduly complicated 16 .…”

Section: Introductionmentioning

confidence: 99%

In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

Mohyeldin,

Talaat,

Kamal

et al. 2024

Sci Rep

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Gemigliptin-Rosuvastatin single-pill combination is a promising therapeutic tool in the effective control of hyperglycemia and hypercholesterolemia. Organic sensors with high quantum yields have profoundly significant applications in the pharmaceutical industry, such as routine quality control of marketed formulations. Herein, the fluorescence sensor, 2-Morpholino-4,6-dimethyl nicotinonitrile 3, (λex; 226 nm, λem; 406 nm), was synthesized with a fluorescence quantum yield of 56.86% and fully characterized in our laboratory. This sensor showed high efficiency for the determination of Gemigliptin (GEM) and Rosuvastatin (RSV) traces through their stoichiometric interactions and simultaneously fractionated by selective solvation. The interaction between the stated analytes and sensor 3 was a quenching effect. Various experimental parameters and the turn-off mechanism were addressed. The adopted approach fulfilled the ICH validation criteria and showed linear satisfactory ranges, 0.2–2 and 0.1–1 μg/mL for GEM and RSV, respectively with nano-limits of detection less than 30 ng/mL for both analytes. The synthesized sensor has been successfully applied for GEM and RSV co-assessment in their synthetic polypill with excellent % recoveries of 98.83 ± 0.86 and 100.19 ± 0.64, respectively. No statistically significant difference between the results of the proposed and reported spectrophotometric methods in terms of the F- and t-tests. Ecological and whiteness appraisals of the proposed study were conducted via three novel approaches: the Greenness Index via Spider Diagram, the Analytical Greenness Metric, and the Red–Green–Blue 12 model. The aforementioned metrics proved the superiority of the adopted approach over the previously published one regarding eco-friendliness and sustainability. Our devised fluorimetric turn-off sensing method showed high sensitivity, selectivity, feasibility, and rapidity with minimal cost and environmental burden over other sophisticated techniques, making it reliable in quality control labs.

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Section: Introductionmentioning

confidence: 99%

In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

Mohyeldin,

Talaat,

Kamal

et al. 2024

Sci Rep

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A Chalcone-based Fluorescence Probe for H2S Detecting Utilizing ESIPT Coupled ICT Mechanism

et al. 2023

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The accurate and effective identi cation of hydrogen sul de holds great signi cance for environmental monitoring. Azide-binding uorescent probes are powerful tools for hydrogen sul de detection. We combined the 2'-Hydroxychalcone scaffold with azide moiety to construct probe Chal-N 3 , the electronwithdrawing azide moiety was utilized to block the ESIPT process of 2'-Hydroxychalcone and quenches the uorescence. The uorescent probe was triggered with the addition of hydrogen sul de, accompanied by great uorescence intensity enhancement with a large Stokes shift. With excellent uorescence properties including high sensitivity, speci city selectivity, and wider pH range tolerance, the probe was successfully applied to natural water samples.

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Difunctional Fluorescent Probes for Iron and Hydrogen Sulfide Detection Based on Diphenyl Derivative

Shang

Liu

et al. 2023

J Fluoresc

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In order to better monitor the content of Fe 3+ and H 2 S in the biological environment, two new uorescent probes were designed and synthesized. With the addition of Fe 3+ , the strong uorescence emission of two probes was signi cantly quenched due to the paramagnetic effect of Fe 3+ . After the addition of S 2− , the uorescence intensity of two probes was quickly restored. Two probes showed high selectivity and strong sensitivity for the detection of Fe 3+ and S 2− , and the uorescence intensity "ON-OFF-ON" was accompanied with the interaction process. At the same time, two probes displayed good anti-interference ability which was not interfered by the existence of other ions. In addition, two probes illustrated fast response time to Fe 3+ , S 2− and small cytotoxicity to cells. Therefore, two probes can provide a potential ideal tool for detecting Fe 3+ and H 2 S in organisms and the environment.

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Enantioselective effect of chiral prothioconazole on the conformation of bovine serum albumin

Cited by 16 publications

References 46 publications

In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

A Chalcone-based Fluorescence Probe for H2S Detecting Utilizing ESIPT Coupled ICT Mechanism

Difunctional Fluorescent Probes for Iron and Hydrogen Sulfide Detection Based on Diphenyl Derivative

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