Enantioselective determination of terazosin in human plasma by normal phase high-performance liquid chromatography–electrospray mass spectrometry

Zavitsanos, A.Paul; Alebic-Kolbah, Tanja

doi:10.1016/s0021-9673(97)00892-3

Cited by 56 publications

(31 citation statements)

References 3 publications

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“…Additional safety measurements regarding the use of hexane in conjunction with HPLC/MS are described elsewhere. 25,26 All experiments were repeated using a turbo ion-spray (TISP) interface. In this interface, a stream of heated dry nitrogen is directed at the droplets produced by ion-spray.…”

Section: Methodsmentioning

confidence: 99%

Mass spectrometric characterization of polyhedral oligosilsesquioxanes and heterosilsesquioxanes

Bakhtiar

Feher

1999

Rapid Commun. Mass Spectrom.

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The term 'silsesquioxane' refers to structures with an even number of silicon atoms (i.e. [RSiO 3/2 ] n with n = even integer) and extended network solids (i.e. [RSiO 3/2 ]) which can achieve the idealized empirical formula for silsesquioxanes, (RSiO 3/2 ) ? . In order to avoid confusion, it is often useful to distinguish between 'fully condensed' and 'incompletely condensed' silisesquioxane frameworks. A fully condensed silsesquioxane has an empirical formula of [RSiO 3/2 ] n , whereas an incompletely condensed silsesquioxane possesses reactive Si-OH groups. A host of heterosilsesquioxanes including main-group, transitionmetal and lanthanide metallasilsesquioxanes are also available via functionalization of incompletely condensed silsesquioxanes. Recent applications include soluble models for silica-supported catalysts, and precursors to hybrid inorganic/organic materials. 1-14 For these reasons metallasilsesquioxanes generated from the coordination of incompletely condensed silsesquioxanes to high-valent transition metals have emerged as useful solution-state models for silica-supported catalysts.15 A wide range of silsesquioxanes can be prepared via the hydrolytic condensation reactions of trifunctional organosilicon monomers, as presented in Scheme 1.Herein, using mass spectrometry, we present evidence on the generation and characterization of a selected group of silsesquioxanes in neat hexane or n-hexane/ethanol (i.e. 90:10, v/v). The results in this study indicate that atmospheric pressure chemical ionization (APCI) and turbo ionspray (TISP) mass spectrometry (MS) could be useful Scheme 1.

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Section: Methodsmentioning

confidence: 99%

Mass spectrometric characterization of polyhedral oligosilsesquioxanes and heterosilsesquioxanes

Bakhtiar

Feher

1999

Rapid Commun. Mass Spectrom.

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“…Alebic-Kolbah and Zavitsanos 45,46 reported an elegant series of normal-phase LC/APCI/MS/MS chiral assays for several pharmaceutical products using a Chiralpak AD column (a polysaccharide-based chiral column). The CSP used was a Daicel's amylose tris(3,5-dimethylphenylcarbamate) coated on a silica gel support.…”

Section: Enantioselective Chromatography/ Mass Spectrometrymentioning

confidence: 99%

Use of atmospheric pressure ionization mass spectrometry in enantioselective liquid chromatography

2001

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Recent advances in mass spectrometry have rendered it an attractive and versatile tool in industrial and academic research laboratories. As a part of this rapid growth, a considerable body of literature has been devoted to the application of mass spectrometry in studies involving enantioselectivity, molecular recognition, and supramolecular chemistry. In concert with separation techniques such as capillary electrophoresis and liquid chromatography, mass spectrometry allows rapid characterization of a large array of molecules in complex mixtures. A majority of these findings have been made possible by the introduction of 'soft-ionization' techniques such as electrospray ionization interface. Other techniques such as atmospheric pressure chemical ionization mass spectrometry have been widely used as a rugged interface for quantitative liquid chromatography-mass spectrometry. Herein, we present a brief overview of the above techniques accompanied with several examples of enantioselective capillary electrophoresis- and liquid chromatography-mass spectrometry in drug discovery and development. Although the emphasis of this article is on quantitative enantiomeric chromatography-mass spectrometry, we envisage that similar strategies are adaptable in qualitative studies.

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“…Several methods for determination of this drug have been reported in the literature, including high performance liquid chromatography [5][6][7][8][9][10][11][12][13][14][15][16], capillary zone electrophoresis [17], spectrofluorimetry [18,19], X-ray fluorescence spectrometry based on the formation of ion-pair associates with zinc thiocyanate [20] and voltammetric methods [19,20]. Electrochemical methods have received considerable interest due to their higher selectivity, lower detection limit, lower cost and faster operation than other reported methods [21,22].…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

Atta

BinSabt

Hassan³

et al. 2017

Crystals

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Electrochemical sensor was fabricated based on carbon paste electrode modified with an ionic liquid crystal ILC (2-chloro-1,3-dimethyl-imidazolidinium hexafluorophosphate) in presence of sodium dodecyl sulfate for the selective electrochemical determination of Terazosin (TZ) in presence of common interference compounds. The electrode performance was compared in presence of other ionic liquids ILs (1-Butyl-4-methyl pyridinium tetrafluoroborate) and (1-n-Hexyl-3-methyl imidazolium tetrafluoroborate). Ultrasensitive determination of Terazosin HCl at the ILC modified electrode in the linear dynamic ranges of 0.002 to 0.09 µmol·L −1 and 0.2 to 30 µmol·L −1 with correlation coefficients 0.996 and 0.995 and LODs 1.69 × 10 −11 mol·L −1 and 6.43 × 10 −9 mol·L −1 , respectively, were obtained. Selective determination of TZ in presence of uric acid and ascorbic acid and simultaneous determination of binary mixtures of TZ/dopamine, TZ/paracetamol and TZ/Morphine were also determined successfully using the modified sensor.

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Enantioselective determination of terazosin in human plasma by normal phase high-performance liquid chromatography–electrospray mass spectrometry

Cited by 56 publications

References 3 publications

Mass spectrometric characterization of polyhedral oligosilsesquioxanes and heterosilsesquioxanes

Mass spectrometric characterization of polyhedral oligosilsesquioxanes and heterosilsesquioxanes

Use of atmospheric pressure ionization mass spectrometry in enantioselective liquid chromatography

Ionic Liquid Crystals Modifier for Selective Determination of Terazosin Antihypertensive Drug in Presence of Common Interference Compounds

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