Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles
Ling-Feng Jiang,
Shao-Hua Wu,
Yu-Xuan Jiang
et al.
Abstract:Chiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic systems and substrate scope. Herein, we report an enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides with a readily available and potent azido transfer reagent via copper catalysis, which affords a variety of chiral 1,2,3-triazoles with up … Show more
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