Enantioselective analysis of oxybutynin and N-desethyloxybutynin with application to an in vitro biotransformation study☆

Hollow-Fiber Liquid-Phase Microextraction and Chiral LC–MS/MS Analysis of Venlafaxine and its Metabolites in Plasma

“…This technique, which uses very low amounts of organic solvents and has demonstrated high selectivity, was first introduced in 1999 by Pedersen-Bjergaard and Rasmussen [11]. In this technique the pores of a hydrophobic hollow-fiber are impregnated with an organic solvent and its lumen is filled with an acceptor phase [11,12]. After that the fiber is immersed in the sample (donor phase) and the extraction is performed under agitation for a predetermined period of time.…”

Morphological changes in the salivary acini after in vivo cholinergic stimulation

“…For oxybutynin, N‐desethyloxybutynin has been shown as the active metabolite . The effects of oxybutynin metabolites have been extensively studied in vitro, but not in vivo.…”

Application of Oxybutynin Selective Sensors for Monitoring the Dissolution Profile and Assay of Pharmaceutical Dosage Forms

“…It is an anticholinergic medication used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination, by decreasing the muscle spasms of the bladder. [1][2][3] There are many methods described in the literature to determine oxybutynin and its metabolite N-desethyloxybutynin in pure state and pharmaceutical preparations, some of these are: chromatographic, like HPLC [4][5][6] and GC, 7,8 spectrophotometric 9 and potentiometric 10 methods. In the present work, two ion-selective membrane sensors were developed for oxybutynin hydrochloride (OxCl) based on the use of the ion association complexes of OxCl with phosphotungestic acid (Ox-PTA) and phosphomolybdic acid (Ox-PMA).…”