Enantiomers of adrenaline-type amino alcohols by Burkholderia cepacia lipase-catalyzed asymmetric acylation

A New Copper(I)–Tetrahydrosalen‐Catalyzed Asymmetric Henry Reaction and Its Extension to the Synthesis of (S)‐Norphenylephrine

“…[15] [a] 20 D = À1.7 (c = 5.8 in CH 3 OH, 98 % ee)). When 3-phenoxybenzaldehyde 4 e was employed as a substrate, the reaction also provided the corresponding product 5 e in moderate yield with excellent enantioselectivity (Table 2, entry 5).…”

Amino acid residues involved in the interaction with the intrinsic agonist (R)-octopamine in the .BETA.-adrenergic-like octopamine receptor from the silkworm Bombyx mori

“…After 17-21 hr, attached cells were washed once with Dulbecco's phosphate-buffered saline (D-PBS) (1 mL; Invitrogen) and preincubated in D-PBS (1.8 mL) containing 100 m M 3-isobutyl-1-methylxanthine (IBMX) for 20 min at 37°C. After preincubation, 200-m L aliquots of D-PBS containing various concentrations of (R)-OA 11) were added to the dishes, and the cultures were incubated for 20 min at 37°C. The reactions were stopped by aspirating the media and adding ice-cold acidic ethanol (1 M HCl : ethanolϭ1 : 100; 300 m L).…”

Functional and pharmacological characterization of a β-adrenergic-like octopamine receptor from the silkworm Bombyx mori

“…(R)-and (S)-OA were prepared according to the method described by Lundell et al (2004). TA, tolazoline, and yohimbine were obtained from SigmaeAldrich (St. Louis, MO).…”