Enantiomeric Separation of (R)-5-(1-Hydroxyethyl)-2-(pyridine- 2-yl)-[1, 3, 4]-thiadiazole, an Intermediate of Nafithromycin on Immobilized Amylose Based Stationary Phase

A New Process for the Synthesis of R‐nosylate a Key Intermediate of Nafithromycin

“…Additionally, we have previously described the chiral HPLC technique for determining the enantiomeric purity of 14 and 3 b. [17,18] The synthetic scheme for synthesis of 3 b is represented in Scheme 3. The process of novel synthetic route (Scheme 3) process optimization is dynamic in terms of cost, yields, cycle time, and industrial viability, among other factors.…”

“…The new method has a number of significant benefits, including the use of DCM as a single solvent in three of the six steps and the use of non‐potentially hazardous reagents (with the exception of Lawesson's reagent). Additionally, we have previously described the chiral HPLC technique for determining the enantiomeric purity of 14 and 3 b [17,18] . The synthetic scheme for synthesis of 3 b is represented in Scheme 3.…”