Enantiomeric Separation of Indole-3-Propanamide Derivatives by Using Supercritical Fluid Chromatography on a Polysaccharide-Based Chiral Stationary Phase
Abstract:Thirteen pairs of I3P enantiomers were screened using nine polysaccharide chiral stationary phases and three different mobile phases. The purification strategy for 13 pairs of I3P enantiomers were designed and optimized considering enantiomeric purity and enrichment of isomers. Out of 13 I3P derivatives which were screened using supercritical fluid chromatography, 10 derivatives displayed excellent baseline separation using a Lux Cellulose—4 column and their resolution from higher to lower order of I3P-11, 13,… Show more
“…The RMSD, RMSF, and total energy of the complexes were examined using event analysis and simulation-interaction diagrams. The simulation was done for up to 100 ns [ 42 ].…”
“…The RMSD, RMSF, and total energy of the complexes were examined using event analysis and simulation-interaction diagrams. The simulation was done for up to 100 ns [ 42 ].…”
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