Eur. J. Chem. volume 7, issue 3, P357-362 2016 DOI: 10.5155/eurjchem.7.3.357-362.1470
Ahmed Abd-Alazim Mostafa
Abstract:

The enantiomeric separation of warfarin (WAR) enantiomers and its hydroxy metabolites positional isomers is described in this work. The utilization of chiral chromatography coupled to Tandem mass spectrometry helps to achieve that. The developed method was able to separate R,S-warfarin and enantiomers of 4,7,10-hydroxy warfarin in human plasma. Plasma samples were processed with simple protein precipitation with acetonitrile. The chromatographic separation was done on chiral Astec Chirobiotic V column wit…

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