Enantiomer-specific accumulation, depuration, metabolization and isomerization of hexabromocyclododecane (HBCD) diastereomers in mirror carp from water

Zhang, Yanwei; Sun, Hongwen; Ruan, Yuefei

doi:10.1016/j.jhazmat.2013.10.062

Cited by 53 publications

(43 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We showed that little difference existed in diastereomer fractionation during the first week (experiment A) but that a enrichment in biota seems to increase with time of exposure ($20% enriched after 2 to 3 wk in experiments A and B, but $70% after 8 mo in experiment C). In a laboratory experiment with carp, Zhang et al [38] showed a similar increase in the percentage of a-HBCDD over a period of 50 d. We also demonstrated that fractionation in M. balthica does not seem to be dose-dependent within the range of doses tested (experiment C). This is in contrast to Du et al [36], who found concentration-dependent bioaccumulation of the 3 diastereomers from contaminated food in a laboratory experiment with zebrafish.…”

Section: Infaunal Bivalves and Bioaccumulationsupporting

confidence: 81%

“…Although g-HBCDD log BSAFs are comparable between the present study and La Guardia et al [10], a-HBCDD values in the present study (4.5-5.2 in experiment C) are considerably higher than those found by La Guardia et al [10] (0.5-1) for the benthic bivalve Corbicula fluminea. These trends in fractionation may be caused by differences in either bioavailability or assimilation efficiency between the diastereomers [36,37], the fact that a-HBCDD is more persistent and less easily degraded than b and g, or because organisms bioisomerize b and g forms to a or metabolize them to other molecules [10,17,25,36,38]. We showed that little difference existed in diastereomer fractionation during the first week (experiment A) but that a enrichment in biota seems to increase with time of exposure ($20% enriched after 2 to 3 wk in experiments A and B, but $70% after 8 mo in experiment C).…”

Section: Infaunal Bivalves and Bioaccumulationmentioning

confidence: 99%

See 1 more Smart Citation

Effects of benthos, temperature, and dose on the fate of hexabromocyclododecane in experimental coastal ecosystems

Bradshaw

Strid

Stedingk

et al. 2015

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

The authors studied the fate of the brominated flame retardant hexabromocyclododecane (HBCDD) added in a particulate suspension to experimental ecosystems assembled from brackish (Baltic Sea) coastal bays. Two experiments examined how benthic macrofauna (over 21 d) and increased temperature (14 d) affected HBCDD concentrations and fractionation of α, β, and γ diastereomers in the water, sediment, and biota. A third experiment run over 3 seasons (231 d), studied the effect of HBCDD dose on the same endpoints. In all treatments of the 3 experiments, HBCDD partitioned mainly to the sediment, and this proportion increased with time. Presence of macrofauna tended to increase the HBCDD concentration in the sediment and decreased its concentration in the water. Increased temperature (+ 5°C) decreased the amount of HBCDD in sediment and water but not in the filter- and deposit-feeding infaunal bivalves (Macoma balthica). The partitioning between water, sediment, and biota was not concentration dependent. In all treatments, sediment became enriched in γ-HBCDD, M. balthica in α-HBCDD, and water in α- and β-HBCDD. Bioaccumulation of HBCDD in M. balthica was high in all experiments (log biota-sediment accumulation factor [BSAF] > 1.25), the α diastereomer contributing the most (log BSAF 2.1-5.2). There is a risk of trophic transfer of HBCDD from benthic to pelagic food webs, as well as secondary poisoning of marine consumers.

show abstract

Section: Infaunal Bivalves and Bioaccumulationsupporting

confidence: 81%

Section: Infaunal Bivalves and Bioaccumulationmentioning

confidence: 99%

Effects of benthos, temperature, and dose on the fate of hexabromocyclododecane in experimental coastal ecosystems

Bradshaw

Strid

Stedingk

et al. 2015

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…It was hypothesized that the selective enrichment among different species might be due to an enantioselective metabolism (Wu et al, 2010;K€ oppen et al, 2010). Zhang et al (2014) proposed that enantioselectivity might occur during bioisomerization. In conclusion, enantioselectivity seems to be very specific for certain animal species, even between species of the same taxonomic order or a predator and its prey (Janak et al, 2008).…”

Section: Enantiomeric Patternmentioning

confidence: 99%

Review of hexabromocyclododecane (HBCD) with a focus on legislation and recent publications concerning toxicokinetics and -dynamics

Koch

Schmidt-Kötters²,

Rupp

et al. 2015

Environmental Pollution

123

View full text Add to dashboard Cite

“…Although technical HBCDD consists of 70 to 95% of -HBCDD and 5 to 30% of -and -HBCDD, the isomer predominates in wildlife as well as in animal-derived products (Marvin et al, 2011;Koch et al, 2015). This shift is generally ascribed to a rapid degradation of -and -HBCDD compared to -HBCDD, through debromination and hydroxylation (Hakk et al, 2012;Zhang et al, 2014). Moreover, the bio-isomerization of -HBCDD into -and mostly -HBCDD, as well as the recalcitrance of -HBCDD to bio-isomerization has been demonstrated in mammals (Szabo et al, 2010(Szabo et al, , 2011, fishes (Du et al, 2012;Zhang et al, 2014) and birds including laying hens (Fournier et al, 2012;Letcher et al, 2015;Dominguez-Romero et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus)

Jondreville

Cariou

Méda³

et al. 2017

Chemosphere

View full text Add to dashboard Cite

The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in fast-growing (FG) and slow-growing (SG) broilers, through an exposure to a dietary concentration of 50 ng α-HBCDD g feed during 42 and 84 days, respectively. Depuration parameters were assessed in SG broilers successively exposed during 42 days and depurated during 42 days. At market age, SG broilers had ingested 42% more feed than FG broilers, while their body weight gain per g of feed ingested was 34% lower. No isomerization of α- to β- or γ-HBCDD forms occurred, while OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the strain, abdominal fat displayed the highest α-HBCDD concentration on a lipid weight basis, followed leg muscles and then breast muscle, liver and plasma. The accumulation ratios of α-HBCDD were slightly higher in SG (6.7, 2.1, 2.6 and 9.9 in leg muscles, breast muscle, liver and abdominal fat, respectively) than in FG broilers (5.2, 2.2, 1.1 and 8.4, respectively). The elimination half-lives in SG broilers were 20, 12 and 19 d in leg muscles, breast muscle and abdominal fat, respectively, to which dilution through growth contributed for around 50%. The overall assimilation efficiency of α-HBCDD was estimated at 58 and 50% in FG and SG broilers, respectively, while 22 and 17% of α-HBCDD ingested were estimated to be eliminated in excreta as metabolites.

show abstract

Enantiomer-specific accumulation, depuration, metabolization and isomerization of hexabromocyclododecane (HBCD) diastereomers in mirror carp from water

Cited by 53 publications

References 35 publications

Effects of benthos, temperature, and dose on the fate of hexabromocyclododecane in experimental coastal ecosystems

Effects of benthos, temperature, and dose on the fate of hexabromocyclododecane in experimental coastal ecosystems

Review of hexabromocyclododecane (HBCD) with a focus on legislation and recent publications concerning toxicokinetics and -dynamics

Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus)

Contact Info

Product

Resources

About